Geometrical defects of a manufactured feature are limited by form, size and location tolerances. The standardized semantics of those tolerances, i.e. their interpretation on the manufactured feature, presents a lot of drawbacks. We propose new semantics, based on the fitting of a unique theoretical feature on the manufactured feature. The fitting criterion we propose, named minimum volume crite...

EVELOPMENT PROJECTS go in di erent directions and each one presents its own dilemmas. Contradictory perceptions and practices have various consquences for the people a ected, for better or worse. Researching development is therefore crucial to deepen understanding of the risks associated with di erent strategies and the complexity of development paths. Sociologist Ulrich Bech developed the conc...

We consider the problem of testing the roundness of a manufactured object using the nger probing model of Cole and Yap 2]. When the object being tested is a disk and it's center is known, we describe a procedure which uses O(n) probes and O(n) computation time. (Here n = j1=qj, where q is the quality of the object.) When the center of the object is not known, a procedure using O(n) probes and O...

AIM To compare the burning characteristics of the tobacco and paper of manufactured and hand rolled cigarettes, and set a fire safety standard of manufacture to largely reduce the fire risk from discarded cigarettes. METHODS (1) Cigarette extinction test of ignition strength: 40 cigarettes per brand, lit and placed on 15 layers of filter paper, in accordance with ASTM test standard E2187-02. ...

The primary auditory cortex (PAC) is central to human auditory abilities, yet its location in the brain remains unclear. We measured the two largest tonotopic subfields of PAC (hA1 and hR) using high-resolution functional MRI at 7 T relative to the underlying anatomy of Heschl's gyrus (HG) in 10 individual human subjects. The data reveals a clear anatomical-functional relationship that, for the...

BACKGROUND Continuing transmissions of highly pathogenic H5N1 viruses in poultry and humans underscores the need for a rapid response to potential pandemic in the form of vaccine. Recombinant technologies for production of immunogenic hemagglutinin (HA) could provide an advantage over the traditional inactivated vaccine manufacturing process. Generation of stably transfected mammalian cells sec...

The hemagglutinin (HA) of influenza A(H3N2) virus responsible for the 1968 influenza pandemic derived from an avian virus. On introduction into humans, its receptor binding properties had changed from a preference for avian receptors (α2,3-linked sialic acid) to a preference for human receptors (α2,6-linked sialic acid). By 2001, the avidity of human H3 viruses for avian receptors had declined,...

Currently, the point of care testing (POCT) is not fully developed for subtype-specific avian influenza virus detection. In this study, an H5N1 hemaglutinin 1 (HA1) epitope (P0: KPNDAINF) and three modified peptides (P1: KPNTAINF, P2: KPNGAINF, P3: KPNDAINDAINF) were evaluated as POCT elements for rapid detection of avian influenza virus. Based on modeling predictions by Autodock Vina, binding ...

A dramatic rise in the frequency of resistance to adamantane drugs by influenza A H3 viruses, associated with a single amino acid replacement in the viral matrix M2 protein, has occurred in multiple countries worldwide in recent years. We investigated the frequency of adamantane-resistant influenza A H3 viruses in Argentina during the period 20012007. We used reverse transcription followed by p...