OBJECTIVE To determine the most effective tocolytic agent at delaying delivery. DESIGN Systematic review and network meta-analysis. DATA SOURCES Cochrane Central Register of Controlled Trials, Medline, Medline In-Process, Embase, and CINAHL up to 17 February 2012. STUDY SELECTION Randomised controlled trials of tocolytic therapy in women at risk of preterm delivery. DATA EXTRACTION At l...

BACKGROUND Magnesium has anti-nociceptive effects and potentiates opioid analgesia following its systemic and neuraxial administration. However, there is no study evaluating the effects of intravenous (IV) magnesium sulphate (MgSO4) therapy on spinal anaesthesia characteristics in severely pre-eclamptic patients. AIMS The aim of this study was to compare spinal anaesthesia characteristics in ...

BACKGROUND Babies born preterm are at an increased risk of dying in the first weeks of life, and those who survive have a higher rate of cerebral palsy (CP) compared with babies born at term. The aim of this individual participant data (IPD) meta-analysis (MA) was to assess the effects of antenatal magnesium sulphate, compared with no magnesium treatment, given to women at risk of preterm birth...

Aim: To compare the efficacy and safety of magnesium sulphate oral nifedipine in acute tocolysis preterm labor. Study design: Randomized controlled trial. Place duration study: Department Obstetrics & Gynecology, DHQ Hospital, Mirpur from 19th October 2019 to 18th April 2020. Methodology: This study included 178 pregnant women with singletons (18 40 years age) assessed through ultrasonograp...

Hypertensive disorders in pregnancy (HDP) affect 10% of pregnant patients and are the second most common cause of maternal mortality and adverse fetal outcomes in developed countries. HDP is a group of diseases that includes preeclampsia, eclampsia, pregnancy induced hypertension and HELLP syndrome. Inadequate placentation, immune intolerance and genetics are accounted as possible etiological f...

Hypertension in pregnancy is a frequent complication that has substantial adverse perinatal outcomes. Hypertension may be preexisting (chronic) essential or secondary hypertension; a second entity is pregnancy induced (gestational hypertension, preeclampsia). Recent advances have identified newer markers for pregnancy hypertension: several potential candidate genes may explain the apparent fami...

The physiological challenges and metabolic demands of pregnancy increase maternal nutritional requirements for macro and micronutrients, critical for the establishment and maintenance of a healthy pregnancy. Trace elements are essential for a variety of cellular processes, and their deficiency has been linked to complications of pregnancy such as preeclampsia, preterm delivery and small for ges...

Fructose-1,6-bisphosphate aldolase plays an effective role in glucose metabolism and gluconeogenic pathway, and reversibly catalyzes the split of fructose 1,6-bisphosphate into the triose phosphates D-glyceraldehyde phosphate and dihydroxyacetone phosphate. Aldolase has 160 kDa molecular weight and three tissue specific isozymes. Gestational diabetes mellitus is defined as glucose intolerance t...