Introduction . Identical twins are a unique model that can be used to assess the concordance of various diseases, including acute leukemia. It should noted leukemia is characterized with high in cases monovular or placentas adhesion, which confirms development this disease prenatal period. Aim — present clinical case successful diagnosis and treatment lymphoblastic identical twins. Main finding...

myeloid sarcoma of female breast is a rare presentation of acute myeloid leukemia (aml). the tumor mass may precede or occur concurrently with aml, cml, myeloproliferative disorders, and/or myelodysplastic syndromes. histologically, it looks like a large cell lymphoma and can be misdiagnosed. a case referred as a suspected case of large cell lymphoma. initial morphological study with convention...

Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of mature-appearing lymphocytes in blood, bone marrow, lymph nodes, and spleen with a median lymphocyte count of 20-30 × 10(9)/L at the time of diagnosis. In half of the patients, the lymphocyte count doubles over a period of 1-year and cyclic rise up to 50 × 10(9)/L can occur in untreated patients while in others the count...

Abstract Introduction/Objective N/A. Methods/Case Report Acute leukemias with ambiguous lineage encompass those that show no clear evidence of differentiation along a single and account for less than 4% all cases acute often poses diagnostic dilemma. We present challenging case an leukemia in previously healthy 27-year-old male, who presented to the ED fever, dyspnea on exertion, nausea vomitin...

Chronic myeloid leukemia (CML) is thought to arise from a pluripotent hematopoietic stem cell that has undergone a reciprocal translocation between the BCR gene on chromosome 22 and the ABL proto-oncogene on chromosome 9. This rearrangement results in a shortened chromosome 22, designated the Philadelphia (Ph) chromosome. The Ph chromosome has been found in cells from all hematopoietic lineages...

Background: B-cell chronic lymphocytic leukemia is the most frequent leukemia in the western world while T-cell large granular lymphocytic leukemia with cytotoxic (CD8+/CD3+CD4-) immunophenotype is rare. There is much ongoing interest regarding the interaction between T cells and B-cell chronic lymphocytic leukemia cells. Methods: Peripheral blood and bone marrow samples from a 72 year-old-man ...

B-cell chronic lymphocytic leukemia (B-CLL) is characterized by the progressive accumulation of functionally incompetent, mature looking, monoclonal CD5+, CD23+ B lymphocytes in blood, bone marrow, lymph nodes and spleen/liver. CLL B cells express low levels of surface immunoglobulin (Ig)M, IgD (10% of those on normal B cells), CD21, CD22 and CD79b. Close to 99% of B-CLL lymphocytes in peripher...