Tooth hypersensitivity is a common clinical complaint after dental treatment. Objective: This study presents case report of the use diode laser for treating tooth in patient with cantilever fixed partial denture abutment. Case Report: A 23-year-old female presented to Faculty Dentistry, Umm Al-Qura University Makkah, chief pain deeply carious maxillary right first premolar. The was extracted, a...

Objective: As a further part of our chemical and biological studies in this field, we describe the preparations of the properly substituted benzylidenebis-(4-hydroxycoumarin) derivatives 5a-h and 3-(6-oxo-(1H)-benzopyrano[4,3-b]benzopyran-7-yl)-4-hydroxycoumarin derivatives 6a-e. Methods: The synthesized compounds were screened for their in vitro antimicrobial activity against five strains of b...

Eighteen novel 5-phenyl-3-(substitutedthioxoquinazolinonyl) isoxazoles (5a-r) were synthesized by cycloaddition of various chalcones with hydroxylaminehydrochloride (NH2OH.HCl). All the newly synthesized compounds were confirmed by their spectral and analytical data. They were evaluated for antimicrobial, antihelminthic, analgesic and anti-inflammatory activities with an objective to evaluate t...

The first synthesis of α-(trifluoromethyl)-β-lactam ((S)-1) is reported. The route starts from α-(trifluoromethyl)acrylic acid (2). Conjugate addition of α-(p-methoxyphenyl)ethylamine ((S)-3b), generated an addition adduct 4b which was cyclised to β-lactam 5b. Separation of the diastereoisomers by chromatography gave ((αS,3S)-5b). N-Debenzylation afforded the desired α-(trifluoromethyl)-β-lacta...

Form Approved OMB No. 0704-0188 Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this coll...

A new and efficient method for the synthesis of 1-(2,6-dichloro-4-trifluoromethylphenyl)-4-alkyl-1H-[1,2,3]-triazoles by the room temperature 1,3-dipolar cycloaddition of (2-azido-1,3-dichloro-5-trifluoromethyl)benzene with terminal alkynes in the presence of Cu (I) salt as catalyst is reported. All the reactions gave 1,4-disubstituted products with high regioselectivity, as no 1,5-disubstitute...

The large-scale production of clean energy is one of the major challenges society is currently facing. Molecular hydrogen is envisaged as a key green fuel for the future, but it becomes a sustainable alternative for classical fuels only if it is also produced in a clean fashion. Here, we report a supramolecular biomimetic approach to form a catalyst that produces molecular hydrogen using light ...

Prescribed by ANSI Std. Z39.18 Form Approved OMB No. 0704-0188 The public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of information. Send comments regarding this burden estimat...

We report on the synthesis and investigation of two diastereomers (5a and 5b) of a new bicalutamide analog with an asymmetric carbon atom and a chiral sulfoxide group. These bicalutamide analogs are novel androgen receptor antagonists with biological activities that depend significantly on the configuration of their stereogenic centers. We determined the absolute configuration at the SO center ...

We analyse for the first time the genetic diversity within Ptyodactylus oudrii across the Maghreb. Two mitochondrial (12s rRNA and 16s rRNA) and two nuclear (C-mos and ACM4) markers are used. The results confirm the specific status of P. oudrii and show high levels of intraspecific variability, indicative of species complex. Lineages found are geographically concordant, and show similar pattern...