results before boosting, among 176 boosted individuals, 75 (42.6%) had hbsab 10 iu/l and were considered seroprotected. among 101 serosusceptible persons, more than 80% of boosted individuals showed more than twofold increase in cytokines concentration, which meant positive hbsag-specific cell-mediated immunity. mcl of both cytokines after boosting in giv were decreased more than twofold, possi...

To examine the clinical outcomes and return to sport rates after treatment of combined, complete (grade III) injuries anterior cruciate ligament (ACL) medial collateral (MCL).A literature search following databases was completed using key words related combined ACL (MCL) tears: MEDLINE, Embase, Cochrane Controlled Trials Register, Database Systematic Reviews, Cumulative Index Nursing Allied Hea...

Transcriptomes and proteomes of Pseudomonas putida LS46 cultured with biodiesel-derived waste glycerol or waste free fatty acids, as sole carbon sources, were compared under conditions that were either permissive or non-permissive for synthesis of medium chain length polyhydroxyalkanoates (mcl-PHA). The objectives of this study were to elucidate mechanisms that influence activation of biopolyme...

We investigated the expression level of p53 upregulated modulator of apoptosis (PUMA), myeloid cell leukemia-I (MCL-1), and p53 in renal cell carcinoma (RCC) and para-carcinoma tissues, as well as their clinical significance. The expression levels of PUMA, MCL-1, and p53 in RCC and para-carcinoma tissues were measured using immunohistochemical and quantitative real-time PCR methods. Correlation...

The anti-apoptotic protein B cell lymphoma/leukaemia 2 (BCL-2) is highly expressed in neuroblastoma and plays an important role in oncogenesis. In this study, the selective BCL-2 inhibitor ABT199 was tested in a panel of neuroblastoma cell lines with diverse expression levels of BCL-2 and other BCL-2 family proteins. ABT199 caused apoptosis more potently in neuroblastoma cell lines expressing h...

We develop an algorithm for estimating parameters of a distribution sampled with contamination. We employ a statistical technique known as “expectation maximization” (EM). Given models for both member and contaminant populations, the EM algorithm iteratively evaluates the membership probability of each discrete data point, then uses those probabilities to update parameter estimates for member a...

Background: The electron contamination may reduce or even diminish the skin sparing property of the megavoltage beam. The detailed characteristics of contaminant electrons are presented for different field sizes and cases. Materials and Methods: The Monte Carlo code, MCNPX, has been used to simulate 18 MV photon beam from a Varian Linac-2300 accelerator. All dose measurements were car...

Myeloid cell leukemia-1 (Mcl-1), an antiapoptotic Bcl-2 family member, is overexpressed in many types of human cancer and associates with cell immortalization, malignant transformation, and chemoresistance. Glycogen synthase kinase-3beta (GSK-3beta), a key component of the Wnt signaling pathway, is involved in multiple physiologic processes such as protein synthesis, tumorigenesis, and apoptosi...

Background Previous approaches for medial collateral ligament (MCL) reconstruction have been associated with extensive exposure, risk of donor site morbidity with autografts, loss of motion, nonanatomic graft placement, and technical complexity with double-bundle constructs. Therefore, we implemented a technique that uses Achilles allograft, small incisions, and anatomic insertions to reconstru...

REFERENCES 1. Hegde S, Kaushal N, Ravindra KC, et al. delta12-pros-taglandin J3, an omega-3 fatty acid-derived metabolite, selectively ablates leukemia stem cells in mice. 2. Mozaffarian D, Lemaitre RN, King IB, et al. Circulating long-chain omega-3 fatty acids and incidence of congestive heart failure in older adults: the cardiovascular health study: a cohort study. polyunsaturated fatty acids...