Oropharyngeal candidiasis (OPC) is among the most common opportunistic infections observed in persons infected with human immunodeficiency virus. A once-daily miconazole 50 mg mucoadhesive buccal tablet (MBT) is a novel delivery system with potent in vitro activity against many Candida species, including some that may be resistant to other azoles. MBT, although more expensive, offers an effecti...

We examine the question of solving the extinction probability of a particular class of continuous-time multi-type branching processes, named Markovian binary trees (MBT). The extinction probability is the minimal nonnegative solution of a xed point equation that turns out to be quadratic, which makes its resolution particularly clear. We analyze rst two linear algorithms to compute the extincti...

Maternally synthesized RNAs program early embryonic development in many animals. These RNAs are degraded rapidly by the midblastula transition (MBT), allowing genetic control of development to pass to zygotically synthesized transcripts. Here we show that in the early embryo of Drosophila melanogaster, there are two independent RNA degradation pathways, either of which is sufficient for transcr...

Prior to the midblastula transition (MBT), Xenopus laevis embryos do not engage cell cycle checkpoints, although overexpression of the kinase XChk1 arrests cell divisions. At the MBT, XChk1 transiently activates and promotes cell cycle lengthening. In this study, endogenous XChk1 was inhibited by the expression of dominant-negative XChk1 (DN-XChk1). Development appeared normal until the early g...

A novel ligand, 1-(4-methoxybenzylidene)-4-methylthiosemicarbazone (MBT) derived from 4-methoxybenzaldehyde was synthesized and characterized by spectroscopic methods (IR, H NMR, C NMR), single crystal X-ray diffraction technique and physical means. MBT showed antibacterial activity in vitro with MICs of 64 μg/mL (a strain of Salmonella typhi (ATCC 6539)), 128 μg/mL (Salmonella typhi), 64 μg/mL...

This paper describes tool support that has been implemented for the Test Template Framework (TTF). The TTF is a model-based testing (MBT) method specially well-suited for unit testing from Z specifications. Although the TTF is a sound MBT method and it has been widely referenced since its first publication, attention in recent years has decayed. In fact, some have argued that generating abstrac...

Model-based testing (MBT) studies how to generate test cases from a model of the system under test (SUT). Many MBT methods rely on building an automaton from the model and then they generate test cases by covering the automaton with different path coverage criteria. However, if a model of the SUT is a logical formula over some complex mathematical theories (such as the Z notation) it may be mor...

DNA replication in the embryo of Xenopus laevis changes dramatically at the mid-blastula transition (MBT), with Y RNA-independent random initiation switching to Y RNA-dependent initiation at specific origins. Here, we identify xNuRD, an MTA2-containing assemblage of the nucleosome remodeling and histone deacetylation complex NuRD, as an essential factor in pre-MBT Xenopus embryos that overcomes...

Indian red scorpion (Mesobuthus tamulus; MBT) produces lethal stings and is a matter of concern in certain parts of India. MBT envenomation produces multi-systemic involvement, thus presents difficulty in the management. Symptomatic treatment has been practiced earlier that failed to relieve the toxic effects of the venom. Therefore, present manuscript deals with pathophysiologically based appr...

Background: The COVID-19 infection is a disease, in severe cases of which the mortality rate intensive care unit 42-62%. Its main cause development "cytokine storm" and hypoxia pulmonary injury. It has been proven that hemoperfusion through selective hemosorbents effective for suppressing cytokine aggression. Considering effectiveness hemosorption combination with magnetic blood treatment (MBT)...