Dear Editor, We read with interest the paper “Association between MDM2 SNP309 polymorphism and endometrial cancer risk in Polish women” by Zajac et al. in the „Polish Journal of Pathology” [1]. This paper assesses the impact of the MDM2 promoter SNP309 (rs2279744) on risk of endometrial cancer in Polish women. The data presented by the authors indicate that the SNP309G allele is associated with...

Impairment of the p53 tumor suppressor network 1 is thought to be involved in a large percentage of tumors either by mutations in the p53 gene2–4 or by increased expression of its major control system, the MDM25 (murine double minute 2; HDM2 for its human equivalent). It is important to realize that levels of p53 are subjected to an autoregulatory feedback loop by MDM26,7 as p53 upregulates MDM...