Continuous powder mixing technology (CMT) application during continuous direct compression has emerged as a leading used in the development and manufacture of solid oral dosage forms. The critical quality attributes final product are heavily dependent on performance step directly influences drug attributes. This study investigates impact blend material properties (bulk density, API particle siz...

To clarify which process in renal secretion is responsible for the stereoselective renal secretion of organic anions, the renal handling of enantiomers of 5-monomethylsulfamoyl-6,7-dichloro-2, 3-dihydrobenzofuran-2-carboxylic acid (MBCA) was studied by the multiple-indicator dilution method, using isolated perfused rat kidney. After bolus injection of (R)-(+)-[14C]MBCA or (S)-(-)-[14C]MBCA into...