In current study, a few sheep cystic livers and lungs were obtained from Mashhad slaughter house and protoscolex were separated aseptically. Thirty 6-week-old Swiss mice were divided into 5 groups and two thousands of live protoscolices were inoculated intrapritoaneally in each mouse. In group 1 and 2 (prophylactic groups), mice were given 150 mg/kg of oral albendazole and mebendazole for 10 da...

The purpose of the present study was investigating kinetic and thermodynamic analysis using eudragit (EUD) polymer as controller to drug release mebendazole. nanofibers containing various proportions of EUD polymer, that were prepared with electrospinning technique.  In this study, the amount of drug mebendazole release was investigated using nanofibers containing EUD at concentrations 50, 250,...

A novel method was proposed for the determination of five benzimidazoles (oxfendazole, mebendazole, flubendazole, albendazole, and fenbendazole) using magnetic graphene (G-Fe3O4). G-Fe3O4 was synthesized via in situ chemical coprecipitation. The properties of G-Fe3O4 were characterized by various instrumental methods. G-Fe3O4 exhibited a great adsorption ability and good stability towards analy...

The number of new drug candidates that are cleared via noncytochrome P450 (P450) enzymes has increased. However, unlike oxidation by P450, the roles of reductive enzymes are less understood. The metabolism in intestine is especially not well known. The purposes of this study were to investigate the significance of reductive metabolism in human intestine, and to establish a quantitative predicti...

“Back to nature” is an increased demand nowadays, for using plants in therapy “instead of using synthetic drugs that may have adverse effects. Grape seed extract (Proanthcyanidins) and Selenium possesses a wide array of pharmacological and biochemical actions. Hymenolepiasis and Passulurus infections are considered as common health problems worldwide. In the present study, Grape seed extract an...

1These drugs can be combined with conventional chemotherapeutics such as cisplatin, carboplatin, adriamycin, taxol etc. and enhance tumor cell killing. 2Cytotoxic effects: binding to the microtubule system and disrupting its functions 3Induction of Nuclear Accumulation of p53 : Both FZ and MZ showed an apoptotic effect on the H460 cells 4Increased Half-Life of p53 in Drug-Treated Cells 5Selecti...