Alkaline phosphatases (APs) catalyze the hydrolysis and transphosphorylation of phosphate monoesters. Quantum mechanical, molecular dynamics, and molecular docking techniques were applied to computationally model the catalytic mechanism of human placental AP (PLAP). Kinetic and thermodynamic evaluations were performed for each reaction step. The functional significances of the more important re...

The myriad applications of metal nanoparticle systems have individual demands on their size, shape and electronic states, demanding novel synthetic methods to optimise these properties. Herein we report our method exploiting strong thiol-Pd binding as a precursor for forming small, uniform Pd nanoparticles activation. We validate approach with range characterisation techniques contrast design s...

     Salt crystallization is one of the most powerful weathering agents that may cause a rapid change in the mechanical properties of stones, and thus limit their durability. Consequently, determining the mechanical properties of stones due to salt crystallization is important for natural building stones used in marine environmental and mild climatic conditions, which expose excessive salt crys...

practical applications of conducting polymers such as polyaniline as membranes are particulary limitedbecause of their poor mechanical properties. however by mixing polyaniline with some conventional insulatingpolymers such as nylon and preparation composite films through solvent casting or blending, it seems to be asuitable way in order to increase the mechanical properties of the conducting p...

  Abstract   The effect of mechanical activation using an attrition mill on the particle size of an ilmenite concentrate and its effect on the ability of the concentrate for Iron separation during hydrochloric acid leaching and the kinetics of the dissolution process have been investigated. It was observed that mechanical activation in an attritor significantly enhances the dissolution of iron ...

silica refractory bricks are used especially in the metallurgical industries, due to desirable properties suchas high melting point, rigidity, and high temperatures strength. in this research, different amount of sicwere added to silica refractory containing different binders such as borax, boric acid, calcium nitride,sodium tri poly phosphate, sodium hexa meta phosphate (shmp) and lime. physic...

Recent studies of motor coordination have emphasized the importance of the mechanical properties of muscle in both load compensation-and in the control of movement. Teleologically, different mechanical characteristics may be optimal for different tasks. For example, a skiier may wish to adjust the stiffness of his legs in accordance with the terrain and snow conditions. How, and to what extent ...

Organocatalysts have attracted enormous interest in the water-crosslinking reaction in silane-grafted polyolefins (SGPOs) system owing to their simplicity, low toxicity and environmentally benign nature compared to organotin catalysts, which are most used in SGPOs system. We focus on organophosphorus compounds including four structure types as organocatalysts; phosphoric acids, phosphoric ester...

H-Ryk is an atypical receptor tyrosine kinase which differs from other members of this family at a number of conserved residues in the activation and nucleotide binding domains. Using a chimeric receptor approach, we demonstrate that H-Ryk has impaired catalytic activity. Despite the receptor's inability to undergo autophosphorylation or phosphorylate substrates, we demonstrate that ligand stim...