Solid metallic hip implants have much higher stiffness than the femur bone, causing stress-shielding and subsequent implant loosening. The development of low-stiff using porous structures has been reported in literature. Ti6Al4V alloy is a commonly used biomaterial for implants. In this work, Body-Center-Cubic (BCC), Cubic, Spherical four different porosities (82%, 76%, 70%, 67%) were investiga...

Objective(s): Bioactive silicate ceramics have favorable features for applying as off-the-shelf bone and artificial tissue. Calcium silicate can enhance the generation of an immediate bond with host bone without an intervening rough surface in the bone layer. However, the silicate bioceramics have some drawback regarding their mechanical properties and chemical stabilities. Materials and Method...

Prolonged bedrest and microgravity induce alterations to bone, leading to bone fragility and compromising the quality of life. In this study, we characterized the physicochemical changes, microstructure, and biomechanics of the femurs of female adult rats in response to hindlimb unloading for 21 days. Twenty 6-month-old Wistar female rats were distributed into control (CON) and hindlimb unloadi...

Patients with chronic kidney disease (CKD) have an increased risk of fracture. Raloxifene is a mild antiresorptive agent that reduces fracture risk in the general population. Here we assessed the impact of raloxifene on the skeletal properties of animals with progressive CKD. Male Cy/+ rats that develop autosomal dominant cystic kidney disease were treated with either vehicle or raloxifene for ...

BACKGROUND Bone changes in experimental post-traumatic osteoarthritis occur early after transection of the anterior cruciate. The purpose of this study was to determine whether antiresorptive bisphosphonate therapy could slow or arrest the periarticular bone architecture and mechanical properties in a post-traumatic model of knee osteoarthritis. METHODS Skeletally mature, female New Zealand w...

objective: implants are being used in orthodontics as a reliable mode of anchorage. among other factors, the cortical bone thickness plays a major role in determining the stability of these implants. the objective of this study was to study the relationship of various arch forms and the cortical bone thickness and to determine if the cortical bone thickness varies between various arch forms. th...

Mechanical properties of tibial bone at compressive strain rates of 50-200 s are obtained through Split Hopkinson pressure bar. Cylindrical specimens of 12-15 mm diameter and 2-5 mm thickness were used. The Young’s moduli are calculated from linear portion of stress-strain curves. For both cortical and cancellous part of the bones, the Young’s modulus was found to increase with the increasing s...

A significant risk of femoral neck (FN) fracture exists for men and women with an areal bone mineral density (aBMD) higher than the osteoporotic range, as measured with dual-energy X-ray absorptiometry (DXA). Separately measuring the cortical and trabecular FN compartments and combining the results would likely be a critical aspect of enhancing the diagnostic capabilities of a new technique. Be...