Osteoarthritis (OA) is a multifactorial disease, associated with articular cartilage degeneration and eventually joint destruction. The phases of the disease have been described in detail, and mechanical factors play an important role in the initiation of OA, but many questions remain about its etiology. Swelling of cartilage, one of the earliest signs of damage, is proportional to the amount o...

Matrilin-1 (Matn1), a cartilage-specific peri-cellular and extracellular matrix (ECM) protein, has been hypothesized to regulate ECM interactions and transmit mechanical signals in cartilage. Since Matn1 knock-out (Matn1-/-) mice exhibit a normal skeleton, its function in vivo is unclear. In this study, we found that the anabolic Acan and Col2a transcript levels were significantly higher in wil...

Increasing material’s strength is of particular importance. Improving material’s mechanical properties such as strength could reduce the size and weight of the structure. The size and weight of the structure are among the effective parameters in design. Since the past a variety of methods have been developed to increase the strength of metals that are capable of increasing metals’ strength to a...

Introduction: Nonphysiological mechanical loading may be a contributing factor to the initiation and progression of degenerative diseases of articular cartilage such as osteoarthritis. Previous studies have shown that impact loading can give rise to the "propagation" of cell death from impacted to nonimpacted tissue regions [1], perhaps related to the release of toxic oxygen species and induced...

background: since the treatments of long tracheal leisions are associated with some limitations, tissue enginered trachea is considered as an alternative option. this study aimed at preparing a composite scaffold, based on natural and synthetic materials for tracheal tissue engineering. methods: nine chitosan silk-based scaffolds were fabricated using three freezing rates (0.5, 1, and 2°c/min) ...

one of the most important applications of carbon nanotubes (cnts) is as reinforcement of metal matrix composites, because of their excellent mechanical properties. in this study, al-tio2-multi walled carbon nanotubes (mwcnts) nanocomposite is fabricated using isostatic pressing followed by hot extrusion. mechanical alloying is used to mix powders of aluminium, tio2 and mwcnts. tio2 with the amo...

In this study, we examined whether porcine articular cartilage (PAC) is a suitable and effective anti-adhesive material. PAC, which contained no non-collagenous tissue components, was collected by mechanical manipulation and decellularization of porcine knee cartilage. The PAC film for use as an anti-adhesive barrier was easily shaped into various sizes using homemade silicone molds. The PAC fi...

in this research, the mechanical properties of seven types of nanofilm with differing amounts of silver and silver-clay particles were studied. the elasticity of modulus, tensile strength, toughness, elongation at break, tear strength and color of nanofilms were compared with those of ordinary ldpe film. results showed that the inclusion of nano particles increased the modulus of elasticity, te...

Introduction Among nineteen types of collagen identified in a wide range of vertebrate tissues, type II collagen is one of the most common collagens and forms the principle fibrillar component of cartilage. Alterations of type II collagen are responsible for many joint diseases, such as osteoarthritis. Previous biomechanical studies suggested that mechanical properties of cartilage at the gross...