نتایج جستجو برای: meiotic spindle

تعداد نتایج: 37218  

Journal: :Mechanisms of Development 2001
Y. Panzera M. R. Esteban A. de la Hera C. Goday

A Drosophila gene encoding a novel zinc-finger protein, Meics, was cloned using a monoclonal antibody. The predicted amino acid sequence contains 12 zinc-finger motifs of the C2H2-type. During spermatogenesis, Meics distributes intranuclearly at pre- and post-meiotic stages whereas it relocates to central-spindle microtubules at both meiotic divisions.

Journal: :The Journal of Cell Biology 2001
Mary Howe Kent L. McDonald Donna G. Albertson Barbara J. Meyer

Macromolecular structures called kinetochores attach and move chromosomes within the spindle during chromosome segregation. Using electron microscopy, we identified a structure on the holocentric mitotic and meiotic chromosomes of Caenorhabditis elegans that resembles the mammalian kinetochore. This structure faces the poles on mitotic chromosomes but encircles meiotic chromosomes. Worm kinetoc...

2017
Leah Bury Paula A Coelho Angela Simeone Samantha Ferries Claire E Eyers Patrick A Eyers Magdalena Zernicka-Goetz David M Glover

Establishing the bipolar spindle in mammalian oocytes after their prolonged arrest is crucial for meiotic fidelity and subsequent development. In contrast to somatic cells, the first meiotic spindle assembles in the absence of centriole-containing centrosomes. Ran-GTP can promote microtubule nucleation near chromatin, but additional unidentified factors are postulated for the activity of multip...

Journal: :Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2013
Kexi Yi Boris Rubinstein Rong Li

Mammalian oocyte meiosis encompasses two rounds of asymmetric divisions to generate a totipotent haploid egg and, as by-products, two small polar bodies. Two intracellular events, asymmetric spindle positioning and cortical polarization, are critical to such asymmetric divisions. Actin but not microtubule cytoskeleton has been known to be directly involved in both events. Recent work has reveal...

2015
Qiaozhen Ye Scott C Rosenberg Arne Moeller Jeffrey A Speir Tiffany Y Su Kevin D Corbett

The AAA+ family ATPase TRIP13 is a key regulator of meiotic recombination and the spindle assembly checkpoint, acting on signaling proteins of the conserved HORMA domain family. Here we present the structure of the Caenorhabditis elegans TRIP13 ortholog PCH-2, revealing a new family of AAA+ ATPase protein remodelers. PCH-2 possesses a substrate-recognition domain related to those of the protein...

Journal: :Journal of cell science 2004
Yoshinori Watanabe

Meiosis produces haploid gametes from diploid cells in two stages that in many ways resemble mitosis. However, the regulatory mechanisms governing kinetochore orientation and cohesion at the first meiotic division are different from those at mitosis: sister kinetochores are pulled forwards from the same spindle pole at metaphase, and centromeric cohesion is protected throughout anaphase. Conseq...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2007
Michael N Conrad Chih-Ying Lee Joseph L Wilkerson Michael E Dresser

In meiotic prophase, telomeres associate with the nuclear envelope and accumulate adjacent to the centrosome/spindle pole to form the chromosome bouquet, a well conserved event that in Saccharomyces cerevisiae requires the meiotic telomere protein Ndj1p. Ndj1p interacts with Mps3p, a nuclear envelope SUN domain protein that is required for spindle pole body duplication and for sister chromatid ...

2015
Rie Matsunaga Toshitaka Horiuchi

To avoid multiple pregnancies, it is important to select a single high quality embryo for transfer. Observation of meiotic spindles in oocytes is one way of evaluating embryo developmental competence. The spindle is non-invasively visualized by polarized light microscopy. It is possible to perform ICSI more safely and with optimal timing during meiosis by visualizing the meiotic spindle just be...

2017
Xiaoyu Liu Xiaoyun Liu Dandan Chen Xiuying Jiang Wei Ma

Phospholipase D2 (PLD2) is involved in cytoskeletal reorganization, cell migration, cell cycle progression, transcriptional control and vesicle trafficking. There is no evidence about PLD2 function in oocytes during meiosis. Herein, we analyzed PLD2 expression and its relationship with spindle formation and positioning in mouse oocyte meiosis. High protein level of PLD2 was revealed in oocytes ...

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