We present a 74-year-old male patient with 3-years history of visible discoloration of the glans penis, without subjective complaints. Histopathological examination after incision biopsy revealed a moderate increase in the number of melanocytes in the basal layer with irregular distribution, without melanocytic nests, melanophages in the superficial dermis, and subepidermal sclerosus. No cytolo...

Metastatic melanoma may exhibit clinical or histologic features of blue nevus. Pembrolizumab therapy is associated with regression and tumoral melanosis. We report on a man with widespread metastatic melanoma on pembrolizumab therapy in whom a blue-grey papule developed on the left side of his neck that clinically resembled a blue nevus and histologically showed features of both blue nevus and ...

The concept of neurocutaneous melanosis was described in 1948 by Van Bogaert [1] as a nonfamilial neuroectodermal dysplasia, but the first report of an individual with stigmata of neurocutaneous melanosis was made by Rokitansky [2] in 1861. The criteria to be met for diagnosis are large multiple pigmented skin nevi (more than 20 em in diameter) with an excess of melanotic cells in the leptomeni...

Iris melanoma is a primary intraocular tumor with a high potential risc for metastasis, characterized by the presence of a single or a multiple hyperpigmentation focal areas, or diffuse hyperpigmentation of the anterior epithelium of the iris. This hyperpigmentation is due to an abnormal growth and proliferation of melanocytes. However, not any hyperpigmentation should be handled as a melanom, ...

Pigmented contact dermatitis (PCD) is a noneczematous variant of contact dermatitis, characterized clinically by hyperpigmentation with little or no signs of dermatitis. The term “pigmented contact dermatitis” was coined by Osmundsen, a Danish dermatologist who described an epidemic of melanosis in Copenhagen.[1] In a series of excellent observations and investigations, he proved that the melan...