Group A streptococcal (GAS) invasive disease has become increasingly common in recent years but meningitis caused by GAS is still relatively uncommon(1). Recently, severe and fulminant cases of Group A streptococcal meningitis have been reported(2) but it is rather an uncommon organism causing meningitis beyond neonatal period(3). We report a 10-year-old child with bilateral otitis media leadin...

In the present study, we tested whether maintenance of adequate cerebral perfusion pressure (CPP) by pharmacologically preventing systemic hypotension with dopamine infusion would prevent cerebral ischemia and attenuate energy depletion and neuronal injury even though intracranial pressure remains elevated in a newborn piglet meningitis model. Cerebral blood flow, measured at the end of the exp...

Meningitis is a well-known complication of meningomyelocele, but the problems of its diagnosis and treatment have so far received scant attention. Some children with meningomyelocele have a small neurological deficit and no hydrocephalus. Others with hydrocephalus may benefit from modern treatment and grow up to lead normal lives. The problem of meningitis in meningomyelocele is, therefore, wor...

Despite the fundamental function of neutrophils (polymorphonuclear leukocytes (PMNs)) in innate immunity, their role in Escherichia coli K1 (EC-K1) -induced meningitis is unexplored. Here we show that PMN-depleted mice are resistant to EC-K1 (RS218) meningitis. EC-K1 survives and multiplies in PMNs for which outer membrane protein ...

Elizabethkingia anophelis, recently discovered from mosquito gut, is an emerging bacterium associated with neonatal meningitis and nosocomial outbreaks. However, its transmission route remains unknown. We use rapid genome sequencing to investigate 3 cases of E. anophelis sepsis involving 2 neonates who had meningitis and 1 neonate's mother who had chorioamnionitis. Comparative genomics revealed...

Extraintestinal Escherichia coli (ExPEC), a heterogeneous group of pathogens, encompasses avian, neonatal meningitis, and uropathogenic E. coli strains. While several virulence factors are associated with ExPEC, there is no core set of virulence factors that can be used to definitively differentiate these pathotypes. Here we describe a multiplex of four virulence factor-encoding genes, yfcV, va...

Bacteriology 226 Group B Streptococci 228 Group A Streptococci 229 Streptococcus pneumoniae 231 Other Streptococci 231 Enterococcus species 232 Staphylococcus aureus and Coagulase-Negative Staphylococci 232 Listeria monocytogenes 233 Escherichia coli 233 Klebsiella Species 233 Enterobacter Species 234 Citrobacter Species 234 Serratia marcescens 235 Pseudomonas aeruginosa 235 Salmonella Species ...

Because of their specificity, infections in neonatal units form one of the main clinical problems. Our research involved all neonates (1019) hospitalized in Clinic of Obstetrics and Perinatology within the space of one year. Clinically manifested infections were diagnosed in the total number of 47 (4.6%) newborns, including 23 (2.4%) neonates from the neonatal unit (NU) and 24 (46.2%)--from the...

Seizures in the newborn period constitute a medical emergency. Subtle seizures are the commonest type of seizures occurring in the neonatal period. Myoclonic seizures carry the worst prognosis in terms of long-term neurodevelopmental outcome. Hypoxic-ischemic encephalopathy is the most common cause of neonatal seizures. Multiple etiologies often co-exist in neonates and hence it is essential to...

Seizures in the newborn period constitute a medical emergency. Subtle seizures are the commonest type of neonatal seizures, other types being clonic, tonic, and myoclonic. Myoclonic seizures carry the worst prognosis in terms of long-term neurodevelopmental outcome. Hypoxic-ischemic encephalopathy is the most common cause of neonatal seizures. Multiple etiologies often co-exist in neonates and ...