INTRODUCTION Inflammatory bowel diseases (IBD), comprising Crohn's disease, ulcerative colitis and IBD-unclassified, are chronic recurrent inflammatory disorders of the (large) intestine with a heterogeneous, but often disabling disease presentation. The prevalence of IBD is increasing worldwide and medical therapies are introduced earlier to improve health-related quality of life and postpone ...

The leukemia is considered to be one of the most frequent tumors in childhood. The first line of its treatment is 6-mercaptopurine (6-MP). There are many recorded cytotoxic effects for 6-mercaptopurine on tissues such as liver, pancreas and bone marrow. Nowadays the needs for administration of cytotoxic drugs are increased as the incidence of malignancies increases. So we have to search for a s...

Significant progress in the treatment of acute lymphoblastic leukemia (ALL) children has resulted from development effective chemoand supportive care therapy protocols. The vector further research is aimed at reducing toxicity and long-term side effects. study pharmacogenetic aspects main drugs used ALL – methotrexate 6-mercaptopurine allowed to identify oligonucleotide polymorphisms that corre...

In the above article [Hortelano S and Boscá L (1997) Mol Pharmacol 51:414-421], the authors responded to concerns regarding Figure 2 and provided the uncropped image, which was subsequently analyzed by the journal. In this figure, one lane was removed from the original image because it was not relevant. All lanes were from the same gel, and there was no duplication of lanes. The legend has been...

OBJECTIVE In aortic aneurysms the arterial vessel wall is dilated because of destruction of its integrity, which may lead to lethal vessel rupture. Chronic infiltration of inflammatory cells into the vessel wall is fundamental to aneurysm pathology. We aim to limit aneurysm growth by inhibition of inflammation and reducing endothelial cell (EC) activation with immunosuppressive drug azathioprin...