previous studies have demonstrated the potential of monotherapy with either mesenchymal stem cells (mscs) or estrogen in autoimmune and cuprizone models of multiple sclerosis (ms). the aim of this study was to examine the effects of co-administration of 17β-estradiol (e2) and adipose-derived mesenchymal stem cells (adscs) on remyelination of corpus callosum axons in a cuprizone model of ms. for...

stem cell based treatments are being increasingly explored for their possible potential to treat various cancers. mesenchymal stem cells believed to possess anti-tumor potential and are preferred for their properties like immune privileged nature, ability to migrate to the site of tumor and capability for multilineage differentiation. this tumor tropism property of mscs could be utilized to del...

background: pre-clinical investigation of stem cells for repairing damaged myocardium predominantly used rodents, however large animals have cardiac circulation closely resembling the human heart. the aim of this study was to evaluate whether spect/ct myocardial perfusion imaging (mpi) could be used for assessing sheep myocardium following an acute myocardial infarction (mi) and response to int...

Idiopathic pulmonary fibrosis (IPF) is the most common and severe type of idiopathic interstitial pneumonias (IIP), and which is currently no method was developed to restore normal structure and function. There are several reports on therapeutic effects of adult stem cell transplantations in animal models of pulmonary fibrosis. However, little is known about how mesenchymal stem cell (MSC) can ...

Introduction: Chemokine receptors are found on the surface of stem cells. There have been 19 distinct chemokine receptors described in mammals. Chemokines are major players in migration and homing. Therefore, changes in their levels or function can help us to increase the migratory potential of these cells. Valproic acid differs in structure from other drugs in common use. The way in which Va...

BACKGROUND AND OBJECTIVES Ionizing irradiation is a common treatment for cancer patients and can result in adverse side effects affecting the bone and hematopoietic systems. Although some studies have demonstrated that ionizing radiation can induce apoptosis and senescence in hematopoietic stem cells, little is known about the effects of total body irradiation (TBI) on bone marrow (BM) mesenchy...

Mesenchymal stromal cells (MSCs), sometimes called mesenchymal stem cells, are cultured cells able to give rise to mature mesenchymal cells such as adipocytes, osteoblasts, and chondrocytes, and to secrete a wide range of trophic and immunomodulatory molecules. Evidence indicates that pericytes, cells that surround and maintain physical connections with endothelial cells in blood vessels, can g...

Submit Manuscript | http://medcraveonline.com Abbreviations: AM: Amniotic Membrane; MO: Moringa Oleifera; ITBBR: Institute of Tissue Banking and Biomaterial Research; VEGF: Vascular Endothelial Growth Factor; HGF: Hepatocyte Growth Factor; TGF: Transforming Growth Factor; HLA: Human Leukocyte Antigen; DR: Differential Regulation; MSC: Mesenchymal Stem Cells; SLPI: Secretary Leukocyte Proteinase...

In recent years, globally there is an incredible boost in stem cell research has kindled the expectations of both patients and physicians. Mesenchymal cells (MSCs) seem to represent a future powerful tool regenerative medicine, owing their availability, ease manipulation, therapeutic potential, therefore they are particularly important medical research. capable self-renewing, multipotent progen...

Direct cellular interactions of MDA-MB-231cherry breast cancer cells with GFP-transduced human mesenchymal stroma/stem-like (MSCGFP) in a co-culture model resulted spontaneous cell fusion by the generation MDA-MSC-hyb5cherry GFP hybrid cells. The proliferative capacity MDA-MSC-hyb5 was enhanced about 1.8-fold when compared to parental In contrast induced tumor development vivo within 18.8 days,...