BACKGROUND AND PURPOSE We objectively assessed surface structural changes of the hippocampus in mesial temporal sclerosis (MTS) and assessed the ability of large-deformation high-dimensional mapping (HDM-LD) to demonstrate hippocampal surface symmetry and predict group classification of MTS in right and left MTS groups compared with control subjects. METHODS Using eigenvector field analysis o...

Interictal hypometabolism is commonly found in mesio-temporal lobe epilepsy (MTLE), but its pathophysiology remains incompletely understood. We hypothesized that metabolic changes reflect the preferential networks involved by ictal discharges. We analysed the topography of interictal hypometabolism according to electro-clinical patterns in 50 patients with unilateral hippocampal sclerosis (HS) ...

Frontal lobe epilepsy accounts for only 10-20% of the patients in surgical series, but the incidence in non-surgical patient cohorts seems to be much higher. The typical clinical presentation of the seizures includes contralateral clonic movements, uni- or bilateral tonic motor activity as well as complex automatism. The yield of surface EEG may be limited due to the difficulty in detection of ...

in the last century, neural stem cells are used in a lot of studies for basic and therapeutic investigations. several sources are identified for neural stem cells including embryonic, fetal and adult stem cells. although most of studies have focused in embryonic as well as fetal cells due to their capacity to generate progenies, these cells have some problems such as immunological, availability...

background and objective: temporal lobe epilepsy is hallmarked with neuronal degeneration in some areas of hippocampus and mossy fiber sprouting in dentate area. considering some evidences on neuroprotective and antioxidant activity of silymarin (sm), this study was undertaken to evaluate the preventive effect of this agent on structural changes in hippocampus of kainate-epileptic rats. materia...

Refractory epilepsy is a rare, long-term complication in children with acute leukemia who are receiving chemotherapy. A few studies have reported cases of several patients who developed recurrent complex partial seizures after the initiation of chemotherapy. In these cases, the cause of the refractory seizures was identified as mesial temporal lobe sclerosis. Here, we report on two patients wit...

The occurrence of crossed aphasia as a complication after temporal lobe epilepsy surgery is extremely rare. We report the case of a 47-year-old right-handed patient with drug-resistant mesial temporal lobe epilepsy (MTLE) who developed a transitory aphasic syndrome after a right temporal anterior lobectomy. This syndrome was characterized by anomia, poor verbal fluency, verbal perseveration, an...

It is estimated that one third of patients with seizures have medically intractable epilepsy (MIE) – defined as failure of two antiepileptic medications given at appropriate doses1,2. Temporal lobe epilepsy (TLE) is the most common form of MIE. The most frequent pathologic substrate related to this condition is sclerosis and atrophy of the hippocampus – disease named mesial temporal sclerosis (...

BACKGROUND Very few studies have specifically addressed surgical treatment and outcome of patients with tumor-related temporal lobe epilepsy (TLE). AIM To define the postoperative seizure outcome and the factors that influenced the outcome of patients with tumor-related TLE. MATERIALS AND METHODS We selected patients whose surgical pathology revealed a temporal lobe neoplasm and who had com...