This review paper analyzed publications of adjuvant tamoxifen and aromatase inhibitor use following surgery for breast ductal carcinoma in situ (DCIS). Key endpoint analyses were risk of invasive and noninvasive malignancies and new contralateral breast cancers. Metaanalysis of three studies showed a relative risk of 0.69 (95% confidence interval, 0.60-0.79, P<0.05) for breast malignancies with...

We have read the recently published article entitled “CHADS2 score in predicting cerebrovascular events–a metaanalysis” by Santos et al. 1. They show the results derived from a meta-analysis on the usefulness of CHADS2 score to predict cerebrovascular events. Many strategies have been developed to predict the risk of stroke in patients with atrial fibrillation (AF)2. The majority of these have ...

Data extraction: Data were extracted from FDA and sponsor documents and corroborated with published articles when available. Thirty-day survival was assessed by metaanalysis using a fixed-effects model and time-dependent risk by Kaplan-Meier analysis with Cox proportional hazards regression modeling. Where deaths were described within a range of days after treatment, an extreme assumption was m...

treatment of childhood pneumonia: A systematic review of randomized controlled trials. Indian Pediatr. 2010;47:61-6. 12. Malik A, Taneja DK, Devasenapathy N, Rajeshwari K. Zinc supplementation for prevention of acute respiratory infections in infants: A randomized controlled trial. Indian Pediatr. 2014;51:780-4. 13. Mayo-Wilson E, Imdad A, Junior J, Dean S, Bhutta ZA. Preventive zinc supplement...

Four methods for reviewing a body of research literature – narrative review, descriptive review, vote-counting, and meta-analysis – are compared. Meta-analysis as a formalized, systematic review method is discussed in detail in terms of its history, current status, advantages, common analytic methods, and recent developments. Meta-analysis is found to be underutilized in IS. Suggestions on enco...

CAN J ANESTH 54: 1 www.cja-jca.org January, 2007 8 Hernandez-Diaz S, Varas-Lorenzo C, Garcia Rodriguez LA. Non-steroidal antiinflammatory drugs and the risk of acute myocardial infarction. Basic Clin Pharmacol Toxicol 2006; 98: 266–74. 9 Kearney PM, Baigent C, Godwin J, Halls H, Emberson JR, Patrono C. Do selective cyclo-oxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory dru...