Appropriate diagnosis and treatment of hyperthyroidism during pregnancy are of outmost importance, because hyperthyroidism has major adverse impact on both mother and fetus. Since data on the management of thyroid dysfunction during pregnancy is rapidly evolving, two guidelines have been developed by the American Thyroid Association and the Endocrine society in the last 2 years. We compare here...

Thyroxine (T(4)) and triiodothyronine (T(9)) are rapidly degraded by a purified preparation of myeloperoxidase (MPO) and H(2)O(2) with the formation of iodide and material which remains at the origin on paper chromatography. Deiodination by MPO and H(2)O(2) occurs more readily at pH 7.0 than at pH 5.0 in contrast to iodination by this system which is known to occur more readily at pH 5.0 than a...

Introduction: Thyroidectomy is the treatment of choice for non-toxic compressive Multinodular Goiter (MNG). However, when surgery contraindicated, other therapeutic options should be evaluated. In this case report, non-surgical possibilities are reviewed, and results obtained with Radioiodine Therapy (RAI) after stimulating Recombinant Thyroid-Stimulating Hormone (rhTSH) described. Case report:...

We report on a case of diffuse alveolar haemorrhage in a Chinese woman due to methimazole-induced antineutrophil cytoplasmic antibodies. A literature search for anti-thyroid drugs associated with antineutrophil cytoplasmic antibody-induced diffuse alveolar haemorrhages is reviewed. Diffuse alveolar haemorrhage is a rare complication of thiourea agents and the treatment often requires corticoste...

Thyroid Eye disease is a potentially vison impairing condition for which Teprotumumab has emerged as premier option in managing activity. The primary mechanism of action monoclonal antibody against the insulin-like growth factor-I receptor but large portion remains unknown. In original trial about 10% patients developed hyperglycemia was described self limited and mild. Since commercial release...

In the present investigation, influence of experimentally induced hypothyroidism on pineal karyomorphology was studied in three different species of animals – post pubertal male mice (Mus musculus), adult male rats (Rattus rattus) and neonatal male chicks (Gallus domesticus). Twenty-two animals of each species group were used, divided into two sets of experimental groups, Group A the control gr...

This study investigates the effect of thyroid hormones on the morphology of hippocampal neurons in adult rats. Hypo- and hyperthyroidism were induced by adding 0.02% methimazole and 1% l-thyroxine, in drinking water from 40 days of age, respectively. When the rats were 89 days old their brains were removed and stained by a modified Golgi method and blood samples were collected in order to measu...