نتایج جستجو برای: mhc

تعداد نتایج: 21348  

2014
Weerachai Jaratlerdsiri Janine Deakin Ricardo M. Godinez Xueyan Shan Daniel G. Peterson Sylvain Marthey Eric Lyons Fiona M. McCarthy Sally R. Isberg Damien P. Higgins Amanda Y. Chong John St John Travis C. Glenn David A. Ray Jaime Gongora

The major histocompatibility complex (MHC) is a dynamic genome region with an essential role in the adaptive immunity of vertebrates, especially antigen presentation. The MHC is generally divided into subregions (classes I, II and III) containing genes of similar function across species, but with different gene number and organisation. Crocodylia (crocodilians) are widely distributed and repres...

ژورنال: :iranian journal of veterinary research 0
k. s. choi department of horse/companion and wild animal science, college of ecology and environmental science, kyungpook national university, sangju 37224, republic of korea

ویروس اسهال ویروسی گاو (bvdv) از لحاظ اقتصادی یک پاتوژن مهم صنعت پرورش دام در سراسر دنیا است. bvdv بسته به اثرات آن بر سلول های کشت شده به سیتوپاتیک (cp) و غیر سیتوپاتیک (ncp) دسته بندی می شود. bvdv شناخته شده است که پاسخ ایمنی میزبان را تغییر می دهد. از این، مولکول های کمپلکس سازگاری بافتی اصلی (mhc) کلاس ii نقش محوری در توسعه و عملکرد سیستم ایمنی بازی می کند، و در گاو شامل دو نوع dr و dq هستن...

2017
Tze Hau Lam Meixin Shen Matthew Zirui Tay Ee Chee Ren

The control of gene regulation within the major histocompatibility complex (MHC) remains poorly understood, despite several expression quantitative trait loci (eQTL) studies revealing an association of MHC gene expression with independent tag-single nucleotide polymorphisms (SNPs). MHC haplotype variation may exert a greater effect on gene expression phenotype than specific single variants. To ...

Journal: :Journal of immunology 2006
Neil J Poloso Lisa K Denzin Paul A Roche

MHC class II molecules (MHC-II) associate with detergent-resistant membrane microdomains, termed lipid rafts, which affects the function of these molecules during Ag presentation to CD4+ T cells. Recently, it has been proposed that MHC-II also associates with another type of membrane microdomain, termed tetraspan microdomains. These microdomains are defined by association of molecules to a fami...

Journal: :American journal of physiology. Endocrinology and metabolism 2015
Carlos M Castorena Edward B Arias Naveen Sharma Jonathan S Bogan Gregory D Cartee

To fully understand skeletal muscle at the cellular level, it is essential to evaluate single muscle fibers. Accordingly, the major goals of this study were to determine if there are fiber type-related differences in single fibers from rat skeletal muscle for: 1) contraction-stimulated glucose uptake and/or 2) the abundance of GLUT4 and other metabolically relevant proteins. Paired epitrochlear...

2014
Jonatan Tuncel Sabrina Haag Anthony C. Y. Yau Ulrika Norin Amelie Baud Erik Lönnblom Klio Maratou A. Jimmy Ytterberg Diana Ekman Soley Thordardottir Martina Johannesson Alan Gillett Pernilla Stridh Maja Jagodic Tomas Olsson Alberto Fernández-Teruel Roman A. Zubarev Richard Mott Timothy J. Aitman Jonathan Flint Rikard Holmdahl

Genetic variation in the major histocompatibility complex (MHC) affects CD4∶CD8 lineage commitment and MHC expression. However, the contribution of specific genes in this gene-dense region has not yet been resolved. Nor has it been established whether the same genes regulate MHC expression and T cell selection. Here, we assessed the impact of natural genetic variation on MHC expression and CD4∶...

Journal: :The Journal of antibiotics 1995
K Ito T Kobayashi Y Moriyama K Toshima K Tatsuta T Kakiuchi M Futai H L Ploegh K Miwa

We screened natural chemical compounds which inhibit the expression of newly-synthesized MHC class II molecules on the cell surface. IFN-gamma stimulates Colo 205 adenocarcinoma cells to induce the expression of MHC class I, MHC class II, and ICAM-1 molecules on the cell surface. We show here that concanamycin B inhibits the expression of MHC class II molecules on Colo 205 cells, whereas it doe...

Journal: :Journal of immunology 2011
Parimal Majumder Jeremy M Boss

Cohesin is a multiprotein, ringed complex that is most well-known for its role in stabilizing the association of sister chromatids between S phase and M. More recently, cohesin was found to be associated with transcriptional insulators, elements that are associated with the organization of chromatin into regulatory domains. The human MHC class II (MHC-II) locus contains 10 intergenic elements, ...

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