نتایج جستجو برای: mhc class ii

تعداد نتایج: 943960  

Journal: :The Journal of Experimental Medicine 1994
P Romagnoli R N Germain

Invariant chain (Ii) contributes in a number of distinct ways to the proper functioning of major histocompatibility complex (MHC) class II molecules. These include promoting effective association and folding of newly synthesized MHC class II alpha and beta subunits, increasing transit of assembled heterodimers out of the endoplasmic reticulum (ER), inhibiting class II peptide binding, and facil...

Journal: :The Journal of Experimental Medicine 1994
A Woods H Y Chen M E Trumbauer A Sirotina R Cummings D M Zaller

Transgenic mice expressing human major histocompatibility complex (MHC) class II molecules would provide a valuable model system for studying human immunology. However, attempts to obtain human class II-restricted T cell responses in such transgenic mice have had only limited success, possibly due to an inability of mouse CD4 to interact efficiently with human MHC class II molecules. To circumv...

2014
Weerachai Jaratlerdsiri Janine Deakin Ricardo M. Godinez Xueyan Shan Daniel G. Peterson Sylvain Marthey Eric Lyons Fiona M. McCarthy Sally R. Isberg Damien P. Higgins Amanda Y. Chong John St John Travis C. Glenn David A. Ray Jaime Gongora

The major histocompatibility complex (MHC) is a dynamic genome region with an essential role in the adaptive immunity of vertebrates, especially antigen presentation. The MHC is generally divided into subregions (classes I, II and III) containing genes of similar function across species, but with different gene number and organisation. Crocodylia (crocodilians) are widely distributed and repres...

Journal: :Molecular biology and evolution 2011
Aines Castro-Prieto Bettina Wachter Simone Sommer

For more than two decades, the cheetah (Acinonyx jubatus) has been considered a paradigm of disease vulnerability associated with low genetic diversity, particularly at the immune genes of the major histocompatibility complex (MHC). Cheetahs have been used as a classic example in numerous conservation genetics textbooks as well as in many related scientific publications. However, earlier studie...

2012
Tobias Ulbricht Mohammad Alzrigat Almut Horch Nina Reuter Anna von Mikecz Viktor Steimle Eberhard Schmitt Oliver H. Krämer Thomas Stamminger Peter Hemmerich

Promyelocytic leukemia (PML) nuclear bodies selectively associate with transcriptionally active genomic regions, including the gene-rich major histocompatibility (MHC) locus. In this paper, we have explored potential links between PML and interferon (IFN)-γ-induced MHC class II expression. IFN-γ induced a substantial increase in the spatial proximity between PML bodies and the MHC class II gene...

Journal: :Blood 1998
K J Kao M L del Rosario

It has been shown that peripheral-blood mononuclear leukocytes (MNL) are responsible for transfusion-induced alloimmunization to donor major histocompatability complex (MHC) antigens. However, it is not known which subset of MNL is responsible for this immune response. Because elimination of class-II MHC antigen-positive passenger leukocytes effectively prolongs the survival of allografts, it h...

Journal: :Journal of immunology 2001
B P Shum L Guethlein L R Flodin M A Adkison R P Hedrick R B Nehring R J Stet C Secombes P Parham

Rainbow trout (Oncorhynchus mykiss) and brown trout (Salmo trutta) represent two salmonid genera separated for 15--20 million years. cDNA sequences were determined for the classical MHC class I heavy chain gene UBA and the MHC class II beta-chain gene DAB from 15 rainbow and 10 brown trout. Both genes are highly polymorphic in both species and diploid in expression. The MHC class I alleles comp...

2016
Rui Ruan Jue Ruan Xiao-Ling Wan Yang Zheng Min-Min Chen Jin-Song Zheng Ding Wang

Little is known about the major histocompatibility complex (MHC) in the genome of Yangtze finless porpoise (Neophocaena asiaeorientalis asiaeorientalis) (YFP) or other cetaceans. In this study, a high-quality YFP bacterial artificial chromosome (BAC) library was constructed. We then determined the organization and characterization of YFP MHC class II region by screening the BAC library, followe...

Journal: :The Journal of Cell Biology 1997
Monique J. Kleijmeer Stanislaw Morkowski Janice M. Griffith Alexander Y. Rudensky Hans J. Geuze

In most human and mouse antigen-presenting cells, the majority of intracellular major histocompatibility complex (MHC) class II molecules resides in late endocytic MHC class II compartments (MIICs), thought to function in antigen processing and peptide loading. However, in mouse A20 B cells, early endocytic class II-containing vesicles (CIIVs) have been reported to contain most of the intracell...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید