The stability and function of a microbial community depends on nutritional interactions among community members such as the cross-feeding of essential small molecules synthesized by a subset of the population. In this review, we describe examples of microbe-microbe and microbe-host cofactor cross-feeding, a type of interaction that influences the forms of metabolism carried out within a communi...

Microbial and plant specialized metabolites, also known as natural products, are key mediators of microbe-microbe and host-microbe interactions and constitute a rich resource for drug development. In the past decade, genome mining has emerged as a prominent strategy for natural product discovery. Initially, such mining was performed on the basis of individual microbial genome sequences. Now, th...

Infectious diarrhoea is an intestinal disturbance caused by a pathogenic microbe. One of the body's responses to such an infection is to try to flush the microbe out of the intestine. This occurs by water flowing from the body into the intestinal space and by increased intestinal muscle contractions. With more water in the intestine and the content travelling more quickly, the person experience...

The metabolic capabilities of many environmentally and medically important microbes can be quantitatively explored using systems biology approaches to metabolic networks. Yet, as we learn more about the complex microbe-microbe and microbe-environment interactions in microbial communities, it is important to understand whether and how system-level approaches can be extended to the ecosystem leve...

Interactions with microbial communities can have profound influences on animal physiology, thereby impacting animal performance and fitness. Therefore, it is important to understand the diversity and nature of host-microbe interactions in various animal groups (invertebrates, fish, amphibians, reptiles, birds, and mammals). In this perspective, I discuss how the field of host-microbe interactio...

Secondary plant compounds are important signals in several symbiotic and pathogenic plant-microbe interactions. The present review is limited to two groups of secondary plant compounds, flavonoids and strigolactones, which have been reported in root exudates. Data on flavonoids as signaling compounds are available from several symbiotic and pathogenic plant-microbe interactions, whereas only re...

Nowadays medicines believe that the only definite method to diagnose the existence of Helicobacter pylori microbe is performing endoscope, however it’s painful and insufferable for young children. Thus in this paper we used data mining algorithms to diagnose the existence of this microbe and eventually we succeeded in predicting the existence of this bacterium in stomach that guides medicines t...

Sometimes it seems as if horror is the only story that science has to tell, or the only one we want to hear. Somebody has a gadget they have to build, an experiment too sweet to resist. .. The tug of war between beauty and horror is the theme of " Doctor Atomic. When I was a boy, I looked out into the star-filled sky one night and was awestruck by its beauty. .. A few days later, I happened on ...

Dead-end ultrafiltration (DEUF) is an alternative approach to tangential-flow hollow-fiber ultrafiltration that can be readily employed under field conditions to recover microbes from water. The hydraulics of DEUF and microbe recovery for a new DEUF method were investigated using 100-liter tap water samples. Pressure, flow rate, and temperature were investigated using four hollow-fiber ultrafil...

Multiple virus particles can infect a target host cell. Such multiple infections (MIs) have significant and varied ecological and evolutionary consequences for both virus and host populations. Yet, the in situ rates and drivers of MIs in virus-microbe systems remain largely unknown. Here, we develop an individual-based model (IBM) of virus-microbe dynamics to probe how spatial interactions driv...