Abstract BACKGROUND Diffuse midline gliomas (DMG) are the most aggressive brain tumors of childhood and young adults, with documented 2-year survival rates <10%. Treatment failure is due in part to function BBB. Intratumoral microdialysis sampling an effective tool determine entry varied agents could help provide a better understanding relationship drug permeability DMG treatment respons...

BACKGROUND Episodes of hyperglycemia are considered to be a secondary insult in traumatically brain-injured patients and have been shown to be associated with impaired outcome. Intensive insulin therapy to maintain a strict glucose level has been suggested to decrease morbidity and mortality in critically ill patients but this aggressive insulin treatment has been challenged. One aspect of stri...

The brain is a complex organ, consisting of blood vessels, neurons, neuronal support cells, and meninges. The extracellular space surrounding the neurons is a very complex microenvironment, containing proteins, growth factors, neurotransmitters, and other small molecules. Microdialysis has been extensively used for sampling analytes from extracellular spaces in tissues. The microdialysis membra...

Optogenetics is a powerful tool for controlling biological functions using light. Optical fibers have been extensively utilized in optical stimulation devices optogenetics. However, the use of results small photo-stimulation region. In this study, micro-LED array were developed to achieve large-area brain large animal, such as macaque monkeys. Planar and linear designed fabricated photo-stimula...