PURPOSE Gene inactivation with homologous recombination in mice is a widely used tool to study gene function. However, many proteins play essential roles in a number of tissues and germline gene inactivation often results in embryonic lethality. To overcome this limitation and to dissect the functions of essential genes beyond embryonic development, we generated mouse rod opsin promoter-control...

  Abstract   Background: Pseudoarthrosis of the tibia poses one of the most challenging treatment   problems in all of orthopedics. The goal of the study was to assess the clinical   outcome of intramedullary rod fixation in its treatment.   Methods: The results of the management for nine patients with pseudoarthrosis of   the tibia with IM rod fixation were reviewed retrospectively between 198...

When a natural gas pipeline ruptures, the adjacent upstream and downstream automatic control valves (ACV) should close quickly to prevent leakage or explosion. The differential pressure set point (DPS) at each valve location is the main criteria for value setting in ACV actions. If the DPS is not properly adjusted, the ACV may mistakenly close or it may not take any actions at a proper ti...

The buckling behavior of rod strings in wellbore is one of the key issues in petroleum engineering. The slender rod strings in vertical wellbore were selected as research objects. Based on the energy method, the critical load formulas of sinusoidal and helical buckling were derived for the string with the bottom of the wellbore pressure. According to the sinusoidal and helical buckling’s geomet...

The grid-to-rod fretting (GTRF) problem in pressurized water reactors is a flow-induced vibration phenomenon that results in wear and failure of the cladding material on fuel rods. Grid-to-rod fretting is responsible for over 70% of the fuel leaks in pressurized water reactors in the U.S. The GTRFinduced wear process involves turbulent flow, mechanical vibration, tribology, and time-varying irr...

Teleost eyes grow throughout life by adding neurons and stretching extant tissue. New retinal neurons of all types are added at the ciliary margin and new rod photoreceptors are inserted throughout retina in the outer nuclear layer (ONL). New rod photoreceptors result from the division of progenitor cells located in the ONL amidst functioning rod photoreceptor cell nuclei, but it is not known h...

At very low light levels the sensitivity of the visual system is determined by the efficiency with which single photons are captured, and the resulting signal transmitted from the rod photoreceptors through the retinal circuitry to the ganglion cells and on to the brain. Although the tiny electrical signals due to single photons have been observed in rod photoreceptors, little is known about ho...