Munzenmaier, Diane H., and Andrew S. Greene. Chronic angiotensin II AT1 receptor blockade increases cerebral cortical microvessel density. Am J Physiol Heart Circ Physiol 290: H512–H516, 2006. First published September 30, 2005; doi:10.1152/ajpheart.01136.2004.—Angiotensin II is known to stimulate angiogenesis in the peripheral circulation through activation of the angiotensin II type 1 (AT1) r...

background and objectives: angiogenesis is essential for growth and metastasis of solid malignancies. tumor vessel count and expression of vascular endothelial growth factor (vegf), a potent angiogenic factor, have been associated with prognosis. this study was designed to assess vessels density by using cd31 and cd105 (endoglin) and their correlation with expression of vegf and proliferative i...

The spatial correlation between arterial wall microvessels and the accumulation of atherosclerotic plaque is well documented. The role of these microvessels in the development of primary and restenotic lesions is not known. To investigate the effect of interventional procedures on arterial wall microvessels, we studied the adventitial microvascularity of porcine coronary arteries subjected to a...

Frisbee, Jefferson C. Reduced nitric oxide bioavailability contributes to skeletal muscle microvessel rarefaction in the metabolic syndrome. Am J Physiol Regul Integr Comp Physiol 289: R307–R316, 2005. First published March 31, 2005; doi:10.1152/ajpregu.00114.2005.—This study tested the hypothesis that chronically elevated oxidant stress contributes to impaired active hyperemia in skeletal musc...

Monocyte chemoattractant protein-1 (MCP-1) has been demonstrated to play a role in tumor progression. The present study examined the MCP-1 expression of colorectal liver metastases and determined whether MCP-1 is related to tumor progression and is a predictive marker for survival after hepatic resection of colorectal liver metastases. Eighty-seven patients with colorectal liver metastases were...

BACKGROUND The invasion of colon cancer is associated with the tumor angiogenesis. Endostatin is an important anti-angiogenic agent, and the additive effect of endostatin with a chemotherapeutic agent, cyclophosphamide, on micrangium has not been established. METHODS Male BALB/c strain nude mice were injected with human colorectal carcinoma cells (HCT-116). The mice were divided into four gro...