Objective: To compare efficacy, safety and tolerance of combination Mifepristone Misoprostol versus alone in induction labour late intrauterine fetal death (>24 weeks).
 Methods: This prospectively study included 160 women with (IUFD) after 24 weeks gestation divided the randomly into two groups each containing 80 women. In Group-A : 200 mg single dose was given hrs Tab (intravaginally)...

BMJ 1992;305:931-2 be assumed not to be., planning a pregnancy. A treatment which minimised the likelihood of a delayed bleed, and therefore the requirement for a pregnancy test, would seem advantageous. The three pregnancies conceived after mifepristone treatment suggests that the next cycle and ovulation may occur without an intervening bleed. As we found no true failures of mifepristone trea...

How to cite this article: Seth S, Nagrath A, Goel N, Low dose Mifepristone (100 mg) for medical termination of pregnancy. Afr J Prm Health Care Fam Med. 2011;3(1), Art. #254, 5 pages. doi:10.4102/phcfm.v3i1.254 Background: Abortion is the most common entity in the practice of obstetrics and gynaecology. Different methods and modes have been opted for until now to find an effective regimen with ...

Labor induction abortion is effective throughout the second trimester. Patterns of use and gestational age limits vary by locality. Earlier gestations (typically 12 to 20 weeks) have shorter abortion times than later gestational ages, but differences in complication rates within the second trimester according to gestational age have not been demonstrated. The combination of mifepristone and mis...

AIM To explore the reversal effect of mifepristone on multidrug resistance (MDR) in drug-resistant human gastric cancer cell line SGC7901/VCR and its mechanisms. METHODS Expression of multidrug resistance-associated protein(MRP) was detected using reverse transcription-polymerase chain reaction(RT-PCR). Flow cytometry was used to assay the expression of P-glycoprotein(P-gp), Bcl-2, Bax, and t...

BACKGROUND Increased levels of cortisol during acute alcohol withdrawal have been linked to cognitive deficits and depression. Preclinical research found that the glucocorticoid Type II receptor antagonist, mifepristone, prevented some of the neurotoxic effects of withdrawal and memory loss. Clinical trials have shown mifepristone effective in the treatment of depression. This study aims to exa...

Mifepristone (RU-486) is the first antiprogesterone drug used for the termination of early pregnancies (6 to 8 weeks pregnancies), a steroid synthesized in the laboratory. It has higher affinity for the progesterone receptor. It also has other potential applications as anticancer and glucocorticoid antagonist. It is desirable to increase its antiprogestational potency and eliminate the antigluc...

In the UK, mifepristone and gemeprost are licensed for medical termination of pregnancy (TOP) in the first trimester up to 63 days' amenorrhoea. Current practice, however, is to use low-dose (200 mg) mifepristone and misoprostol. We report a large cohort study using these drugs for medical TOP in the first trimester after 63 days amenorrhoea. Of 415 patients undergoing the procedure, 392 (95%) ...

Because Ras signaling is frequently activated by major hepatocellular carcinoma etiological factors, a transgenic zebrafish constitutively expressing the kras(V12) oncogene in the liver was previously generated by our laboratory. Although this model depicted and uncovered the conservation between zebrafish and human liver tumorigenesis, the low tumor incidence and early mortality limit its use ...

OBJECTIVE To compare the effectiveness, in terms of complete abortion, of the World Health Organization (WHO)- and the China-recommended protocol for first-trimester medical abortion. METHODS A retrospective analysis of clinical data from women presenting for first trimester medical abortion between January 2009 and August 2010 at reproductive health clinics in Qingdao, Xi'an, Nanjing, Nannin...