Despite affecting an estimated 4 –7% of patients in the ICU and having a high mortality rate, there are currently a limited number of therapeutic options to treat patients with ARDS.1,2 ARMA, the landmark ARDSnet trial in 2000, established the concept of lungprotective ventilation, where subjects with ARDS receiving mechanical ventilation were randomly assigned to a set tidal volume (VT) of eit...

This paper describes a new methodology to inject transient and permanent faults in digital systems. For this purpose, the simulation based fault injector VERIFY (VHDL-based Evaluation of Reliability by Injecting Faults efficientlY) has been developed, which allows fault injection at several abstraction levels of a digital system. The combined approach of injection and analysis of the results en...

We are concerned with the verification of behavioural equivalences for CCS specifications. We consider their axiomatic presentations thus relying on a term rewriting approach to verify the equivalence. In this framework it happens that, while some behavioural equivalences do admit a fmite canonical term rewriting system, the completion of observational congruence diverges. In the paper we prese...

C programs that manipulate list-based dynamic data structures remain a challenging target for static verification. In this paper we employ the dynamic analysis of dsOli to locate and identify data structure operations in a program, and then use this information to automatically annotate that program with assertions in separation logic. These annotations comprise candidate pre/post-conditions an...

This tutorial deals with runtime enforcement and advocates its use as an extension of runtime verification. While research efforts in runtime verification have been mainly concerned with detection of misbehaviors and acknowledgement of desired behaviors, runtime enforcement aims mainly to circumvent misbehaviors of systems and to guarantee desired behaviors. First, we propose a comparison betwe...

This paper describes a uniform approach to the automation of verification tasks associated with while statements, representation functions for abstract data types, generic program units and abstract base classes. Program units are annotated with equations containing symbols defined by algebraic axioms. An operation’s axioms are developed using strategies that guarantee crucial properties such a...

Verification of web applications is a very important problem, and verifying loops is necessary to achieve that goal. However, loop verification is a long studied and very difficult problem. We find that interdependence of iterations is a major cause of this difficulty. We present coexecution a way to model a loop that avoids the problem of iteration interdependence. We introduce the coexecutabi...

This paper describes the use of the B formal method to verify semantic properties of UML graphical models, and the correctness of transformations on these models.

Cell migration plays an important role in many physiological processes. Rho GTPases (Rac1, Cdc42, RhoA) and phosphatidylinositols have been extensively studied in directional cell migration. However, it remains unclear how Rho GTPases and phosphatidylinositols regulate random cell migration in space and time. We have attempted to address this issue using fluorescence resonance energy transfer (...

The capsular polysaccharide glucuronoxylomannan (GXM) of Cryptococcus neoformans has been shown to interfere with neutrophil migration. Although several receptors have been implied to mediate this process, the structural perspectives are unknown. Here, we assess the contribution of 6-O-acetylation and xylose substitution of the (1-->3)-alpha-d-mannan backbone of GXM, the variable structural fea...