The serum concentration of S-100B is reported to reflect the severity of brain damage. The purpose of this study was to determine whether elevated serum S-100B concentrations were related to neuropsychological test performance of patients in the subacute phase of recovery from mild traumatic brain injury (TBI). S-100B concentrations were measured in blood samples taken within 6 h after TBI. Ser...

The aim was to describe epidemiological and medical aspects of 449 cases of traumatic brain injury (TBI) from a well-defined geographical area with a population of 137,000 inhabitants. An episode of disturbed consciousness was a prerequisite for inclusion in the study. The incidence of TBI was 354/100,000 inhabitants. Median age was 23 years, range 0-91 years; 55% were men and 45% were women; 3...

OBJECTIVE To investigate the incidence of corpus callosum injury (CCI) in patients with mild traumatic brain injury (TBI) using brain MRI. We also performed a review of the clinical characteristics associated with this injury. METHODS A total of 356 patients in the study were diagnosed with TBI, with 94 patients classified as having mild TBI. We included patients with mild TBI for further eva...

Traumatic brain injury (TBI) is a frequent and clinically highly heterogeneous neurological disorder with large socioeconomic consequences. TBI severity classification, based on the hospital admission Glasgow Coma Scale (GCS) score, ranges from mild (GCS 13-15) and moderate (GCS 9-12) to severe (GCS ≤ 8). The GCS reflects the risk of dying from TBI, which is low after mild (∼1%), intermediate a...

Aim: This study investigated whether or not partial chronic sleep restriction would unmask residual memory deficits in individuals with a history of a mild TBI. It was hypothesized that 1) there would be a significant difference in performance on attention and memory tasks between the control group and the TBI group, and 2) there would be a significant difference in performance on attention and...

OBJECTIVES To examine whether individuals who experienced a childhood traumatic brain injury (TBI) are at increased risk for subsequent offending behavior, to identify the emotional characteristics of adults who experienced childhood TBI, and to examine whether these predict offending behavior. PARTICIPANTS Individuals from the Canterbury region who had experienced a childhood (<18 years of a...

To evaluate the effects of mild to moderate blast-related traumatic brain injury (TBI) on the microstructure of brain white matter (WM) and neurobehavioral outcomes, we studied 37 veterans and service members (mean age 31.5 years, SD = 7.2; post-injury interval 871.5 days; SD = 343.1), whose report of acute neurological status was consistent with sustaining mild to moderate TBI due to blast whi...

Insulin-like growth factors (IGF) are potent neurotrophic and neurorepair that were recently proposed as biomarkers of traumatic brain injury (TBI) associated psychiatric comorbidities, in particular post-traumatic stress disorder (PSTD). We tested the hypothesis IGF system is differentially deregulated acute early chronic stages TBI, under stress. Plasma IGF1 IGF2 levels evaluated mice 3 weeks...

The neurobiological and neuropathological bases that underlie the neuropsychological deficits associated with traumatic brain injury (TBI), including mild TBI, are further reviewed. The article provides an update on neuroimaging methods and findings in the study of TBI since the author's published address of the 1999 Distinguished Neuropsychologist Award of the National Academy of Neuropsycholo...

Traumatic brain injury (TBI) is a leading cause of death and disability among young adults. CT remains the imaging modality of choice in the acute setting, in order to triage patients requiring emergent surgical intervention or conservative medical management. The vast majority of TBI patients, however, are categorized as mild TBI or concussion. Some patients with mild TBI or concussion have a ...