OBJECTIVE To examine the relationship of mild traumatic brain injuries (TBI) and post-concussive symptoms (PCS) to post injury family burden and parental distress, using data from a prospective, longitudinal study. METHODS Participants included 71 children with mild TBI with loss of consciousness (LOC), 110 with mild TBI without LOC, and 97 controls with orthopedic injuries not involving the ...

it has been estimated that more than 1.7 million individuals suffer a traumatic brain injury (tbi) each year. tbi causes secondary biochemical and metabolic changes which contribute to subsequent tissue damage and associated neuronal cell death. two early and delayed events occur after tbi, which results in neurological deficits. primary injury events include the mechanical damage that occur at...

This study explored premorbid, neurocognitive, behavioral, and familial factors in preschoolers, ages 3-6, who experienced a mild to moderate traumatic brain injury (TBI). Twenty-nine children with TBI, 33 children with mild to moderate injuries to other body regions, and 34 non-injured children participated in the study. Neuropsychological assessments and behavioral measures were administered ...

Cerebral pressure autoregulation (AR) is a complex intrinsic control mechanism which maintains a constant cerebral blood flow (CBF). This mechanism was found to be impaired after traumatic brain injury (TBI) and was suggested to be associated with variety of cerebrovacular abnormalities found after injury, as disturb AR might increases the vulnerability of the brain to secondary ischemic insult...

Traumatic brain injury (TBI) arising from blast exposure during war is common, and frequently complicated by psychiatric morbidity. There is controversy as to whether mild TBI from blast is different from other causes of mild TBI. Anxiety and affective disorders such as Post-traumatic Stress Disorder (PTSD) and depression are common accompaniments of blast injury with a significant overlap in t...

Objective(s):Melatonin is known as an anti-inflammatory agent, and it has been proven to exert neuroprotection through inhibition of cell death (apoptosis) in several models of brain injury.Secondary injury following the primary traumatic brain injury (TBI) results in glial cells activation, especially astrocytes. In fact, astrocyte activation causes the production of pro-inflammatory cytokines...

Traumatic brain injury (TBI) represents a significant public health problem in modern societies. It is primarily a consequence of traffic-related accidents and falls. Other recently recognized causes include sports injuries and indirect forces such as shock waves from battlefield explosions. TBI is an important cause of death and lifelong disability and represents the most well-established envi...

the incidence of traumatic brain injury (tbi) are annually increasing, developed tissue engineering methods could represent the definite remedies for patients with strongly injured central nervous system and have a great effect in the public healthcare cost. the current clinical treatments in tbi display several limitations. furthermore, several therapies, coming from neural tissue engineering ...

BACKGROUND Data limited to emergency department and inpatient visits undoubtedly underestimate the medical charges associated with traumatic brain injury. The objective of this study was to estimate the direct medical charges of pediatric traumatic brain injuries across all clinical settings in one large, pediatric hospital in the United States. METHODS Traumatic brain injuries sustained by c...

OBJECTIVE We aimed to estimate from a societal perspective the 1-year and lifetime direct and indirect costs of traumatic brain injury (TBI) for New Zealand (NZ) in 2010 projected to 2020. METHODS An incidence-based cost of illness model was developed using data from the Brain Injury Outcomes New Zealand in the Community Study. Details of TBI-related resource use during the first 12 months af...