Universal Internet access has become critical to modern life, leading to many explorations of approaches to increase its availability. In this paper we report on a study of one such approach, PAWS, that seeks to understand the technical and social constraints of providing Internet access, free at the point of use, by sharing existing broadband subscribers’ connections. We elaborate the technica...

Background Giant cell arteritis (GCA) is the most common form of large vessel vasculitis. While remission and relapse are primary endpoints in randomized clinical trials (RCTs), a definition response missing. We conducted systematic literature review (SLR) to inform an international task force developing new criteria GCA. Objectives To identify descriptors used measure treatment change disease ...

In many ways my current research efforts were shaped by my experiences at my undergraduate institution, the Rose-Hulman Institute of Technology. Rose-Hulman is a small, primarily undergraduate, engineering school in rural Indiana. As a result, the mathematics department offerings tended towards the eclectic with courses in the traditional core of research mathematics rarely offered. These cours...

Background: Our understanding of how medications such as biologic disease modifying anti-rheumatic drugs and targeted small molecules (b/tsDMARDs) influence activity in RA is based largely on randomized controlled trials (RCTs). However, most U.S. are limited by sample sizes have often excluded patients who older, male, from racial/ethnic minorities. Whether effectiveness b/tsDMARDs varies thes...

In their letter on our recent publication on modeling Jervell and Lange-Nielsen syndrome (JLNS) using human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) (1), Christ et al. question: (i) the role of the delayed rectifier potassium current (IKs) under baseline conditions in the absence of sympathetic stimulation, (ii) the rapid activation kinetics of IKs, and (iii) the causali...

Background The existing EULAR Recommendations for the non-pharmacological core management of hip and knee osteoarthritis (OA) were published in 2013. A considerable number new studies on various treatment modalities have been since then. Hence, it is time to update OA. Objectives objective this project was perform an updated systematic literature review 2013 osteoarthritis, accordingly. Methods...

Background Covid-19 has generated a change in society and people’s daily lives. Patients with rheumatic diseases have suffered physically mentally, both due to mobility restrictions the impact on personal, family, work social life that COVID-19 brought [1-4]. Objectives To examine of pandemic patients diseases. Methods Cross-sectional descriptive study Data collection was done through an online...

Background Polymyalgia rheumatica (PMR) and Giant cell arteritis (GCA) are chronic inflammatory diseases. Despite the progress made in management of these conditions, new unmet needs have emerged particularly terms prevention disease- treatment-related complications. A treat-to-target (T2T) strategy, which has been well established other rheumatic diseases, not yet developed for PMR GCA. Object...

Background The treat-to-target (T2T) concept is not yet a recognized treatment approach in giant cell arteritis (GCA) and polymyalgia rheumatica (PMR). Developing such recommendations an unmet medical need. Objectives To determine therapeutic targets develop GCA PMR. Methods We conducted systematic literature review to retrieve data on outcomes GCA/PMR as well identify the evidence for effectiv...

Background: An increased risk of severe COVID-19 outcomes may be seen in patients with autoimmune diseases on moderate to high daily doses glucocorticoids, as well those comorbidities. However, specific information about SLE is scarce. Objectives: To determine the characteristics associated a multi-national cross-sectional registry SLE. Methods: adult from physician-reported GRA were studied. V...