Ischemic stroke (IS) is responsible for a high death rate and for adult disability worldwide. MiR-146a (rs2910164), miR-149 (rs2292832), miR-196a2 (rs11614913) and miR-499 (rs3746444) are found to be associated with ischemic stroke. However, the results were inconsistent and inconclusive. The present study performed a meta-analysis to get a more precise and comprehensive estimation of the assoc...

The host response to SARS-CoV-2 infection provide insights into both viral pathogenesis and patient management. host-encoded microRNA (miRNA) infection, however, remains poorly defined. Here we profiled circulating miRNAs from ten COVID-19 patients sampled longitudinally age gender matched healthy donors. We observed 55 that were altered in during early-stage disease, with the inflammatory miR-...

Background: LncRNA DLX6-AS1 has been uncovered to exert effects on various cancers. Nevertheless, the impacts of endometrial cancer (EC) development remained obscure. The study explored influence EC progression via microRNA (miR)-374a-3p/zinc-finger protein (ZFX) axis.Methods: cell lines were collected and DLX6-AS1, miR-374a-3p, ZFX levels in detected. cells transfected with constructs examine ...

Abstract Background Cervical cancer is one most common types among females over the world. While its underlying mechanisms remain unclear. Circ-CCDC66 has been revealed to participate in multiple biological functions, and contribute various diseases’ progression. In current study, we aimed demonstrate role of circ-CCDC66 cervical Methods Real-time quantitative PCR (RT-qPCR) was conducted measur...

background:   objective: to understand the changes of mirnas in endometriosis.   materials and methods: with real-time rt-pcr, we investigated the mir-143 and mir-145 expression in eutopic (eu, n=2) and ectopic endometrium (ec, n=11) (from women with endometriosis) (as well as eu+ec, n=11), along with the normal endometrium (en, n=22) (from women without endometriosis, but with leiomyoma). resu...