Old world monkey TRIM5α is a host factor that restricts human immunodeficiency virus type-1 (HIV-1) infection. Previously, we reported that rhesus macaque TRIM5α (RhTRIM5α) restricts HIV-1 production by inducing degradation of precursor Gag. Since suppressor of cytokine signaling 1 (SOCS1) is known to enhance HIV-1 production by rescuing Gag from lysosomal degradation, we examined if SOCS1 is i...

Systemic lupus erythematosus (SLE) is a complex autoimmune disease involving injuries in multiple organs and systems. Exaggerated inflammatory responses are characterized as end-organ damage in patients with SLE. Although the explicit pathogenesis of SLE remains unclear, increasing evidence suggests that dysregulation of cytokine signals contributes to the progression of SLE through the Janus k...

Vascular smooth muscle cells (VSMCs) are indispensible components in foam cell formation. Salusin-β is a stimulator in the progression of atherosclerosis. Here, we showed that salusin-β increased foam cell formation evidenced by accumulation of lipid droplets and intracellular cholesterol content, and promoted monocyte adhesion in human VSMCs. Salusin-β increased the expressions and activity of...

OBJECTIVE To investigate the role and mechanism of suppressor of cytokine signaling 1 (SOCS1) in the regulation and differentiation of C17.2 neural stem cells (NSCs). METHODS In this study, lentiviral (LV)-SOCS1-enhanced green fluorescent protein (EGFP) was constructed and transfected into C17.2 NSCs. There were three groups of C17.2 NSCs: LV-SOCS1-EGFP, LV-EGFP, and phosphate-buffered saline...

Mice lacking suppressor of cytokine signaling-1 (SOCS1) develop a complex fatal neonatal disease. In this study, SOCS1-/- mice were shown to exhibit excessive responses typical of those induced by interferon gamma (IFNgamma), were hyperresponsive to viral infection, and yielded macrophages with an enhanced IFNgamma-dependent capacity to kill L. major parasites. The complex disease in SOCS1-/- m...

ةصلاخلا بكرملل ةدیدج تاقتشم ریضحت ىلا ثحبلا يمری 4,3,1 ةیتلاا تلاعافتلا ءارجا للاخ نم لوزایادایاث : ًلاوأ : ب كرملل فیش ةدعاق ریضحت ) 2 و نیما 5 و تبكرم 4,3,1 لوزا یادایاث ( يلیفو یلكوینلا ضیو عتلا ءارجاو ةدعاقلل يرتسلاا ب كرملا نیو كت ى لا يدؤ یل مویدو صلا دیسكوثیا دو جوب ل ثیلاا تاتیسا ومورب عم ) 3 ( ، يذ لا یازاردیھلا عم ھتلعافم تمت ن 99 % د یازاردیھلا قتشم ریضحتل ) 4 ( فیش دعاوق نم د یدع...

Suppressor of cytokine signaling 1 (SOCS1) mutations are among the most frequent somatic mutations in classical Hodgkin lymphoma (cHL), yet their prognostic relevance in cHL is unexplored. Here, we performed laser-capture microdissection of Hodgkin/Reed-Sternberg (HRS) cells from tumor samples in a cohort of 105 cHL patients. Full-length SOCS1 gene sequencing showed mutations in 61% of all case...

Respiratory syncytial virus (RSV) infection upregulates genes of the suppressor of cytokine signaling (SOCS) family, which utilize a feedback loop to inhibit type I interferon dependent antiviral signaling pathway. Here, we reconstituted RSV nonstructural (NS) protein expression plasmids (pNS1, pNS2, and pNS1/2) and tested whether NS1 or NS2 would trigger SOCS1 and SOCS3 protein expression. The...

Constitutive activation of Janus kinase 2/signal transducers and activators of transcription (JAK2/STAT) signaling has an important role in the oncogenesis of myeloproliferative neoplasms (MPNs) and leukemia. Histone deacetylases (HDACs) inhibitors have been reported to possess anticancer activity through different mechanisms. However, whether HDACs inhibitors suppress JAK2/STAT signaling in MP...

يديوتامورلا لصافلما باهتلا ضيرم180 ةساردلا تلمش :جئاتنلا عافترا نأ جئاتنلا ترهظأ .)اًماع 40.49±12.19 رمعلا طسوتم( يف LDL لدعم و )55.1%(لورتسلوكلا لدعم عافترا راشتنا لدعم عافترا ينب ةيئاصحإ ةوق تاذ ةقلاع دوجو نع تفشك .)51.2%( ىلع ةولاعو .)p=0.002( CRP لا هبسن عافترا و لورتسيلوكلا طاشنو يلكلا لورتسلوكلا ينب ةيباجيإ ةقلاع دوجو انظحلا ،كلذ طاقن رخآ ضرم ةكرتشلما اًماع 28 مادختساب اهسايق تم امك ،ضرلما ...