Introduction: Objectives: To compare the efficacy, safety and tolerance of misoprostol versus dinoprostone gel in induction of labour in the case of late Intra Uterine Fetal Death (IUFD) with unfavourable cervix.Materials and methods: This prospective study included a consecutive series of 40 women gravid up to fourth with IUFD after 28 weeks of gestation between March 2013 to Feb 2014. Women w...

BACKGROUND The conventional timing of misoprostol administration after mifepristone for second trimester medical abortion is 36-48 h, but simultaneous administration, which may make the regimen more convenient, has not been studied. The objective of this randomized comparison study is to compare two intervals of administration of misoprostol after pretreatment with mifepristone for second trime...

BACKGROUND Letrozole is a third-generation selective aromatase inhibitor. Animal data suggested that it might be useful in medical abortion. We performed two pilot studies to assess the feasibility of using letrozole in combination with either mifepristone or misoprostol for termination of pregnancy up to 63 days. STUDY DESIGN We recruited 40 subjects who requested legal termination of pregna...

The objective of this prospective randomized placebo-controlled study was to determine the effectiveness of 400 mug oral and 400 mug vaginal misoprostol administration for cervical priming 3 h prior to manual vacuum aspiration (MVA) under local anesthesia for voluntary termination of pregnancy before 10 weeks of gestation in comparison with placebo oral or placebo vaginal administration (n=40 i...

Objective: To determine Maternal and Fetal outcome in women undergoing induction of labour with low dose misoprostol.
 Method: A cross-sectional study was carried out to the efficacy Misoprostol for labor (IOL) MTI, Lady Reading Hospital (LRH), Peshawar from 21st January 31st December 2021. All pregnant singleton pregnancy cephalic presentation admitted Induction Labor were included study....

BACKGROUND Hemorrhage continues to be a leading cause of maternal death in developing countries. The 2012 World Health Organization guidelines for the prevention and management of postpartum hemorrhage (PPH) recommend oral administration of misoprostol by community health workers (CHWs). However, there are several outstanding questions about distribution of misoprostol for PPH prevention at hom...

Introduction: This study was conducted to evaluate the efficacy of 800µg vaginal misoprostol after wetting alkaline PH vagina with 3% acetic acid in comparison with 800µg vaginal misoprostol alone in the alkaline PH vagina in terminating first trimester pregnancies. Methods: In this clinical trial, a total of 100 healthy women between 20 and 40 years old requesting legal terminat...

OBJECTIVE To compare the impact of 1000 micrograms of self-administered vaginal misoprostol versus self-administered vaginal placebo at home on preoperative cervical ripening in both premenopausal and postmenopausal women before operative hysteroscopy. DESIGN Two separate but identical parallel, randomised, double-blind, placebo-controlled sequential trials, one in premenopausal women and one...

the search continues for a safe effective and cheap method for mid-trimester termination of pregnancy. misoprostol is a strong contender in this respect. the dose schedule is still not fixed. the objective of this study was to compare the efficacy and adverse effects of two dose regimens of vaginal misoprostol for second trimester termination. prospective randomized double blind controlled tria...

Pro-inflammatory cytokines including tumor necrosis factor α (TNFα), IL-1β, IL-6, and IL-8 are potent immune mediators that exacerbate multiple equine diseases such as sepsis and laminitis. Unfortunately, safe and effective cytokine-targeting therapies are lacking in horses; therefore, novel mechanisms of inhibiting cytokine production are critically needed. One potential mechanism for inhibiti...