Dominant mutations in the Cu/Zn-superoxide dismutase (SOD1) cause familial forms of amyotrophic lateral sclerosis (ALS), a fatal disorder characterized by the progressive loss of motor neurons. The molecular mechanism underlying the toxic gain-of-function of mutant hSOD1s remains uncertain. Several lines of evidence suggest that toxicity to motor neurons requires damage to non-neuronal cells. I...

Overdose of acetaminophen (APAP) causes severe centrilobular hepatic necrosis in humans and experimental animals. Here, to explore its mechanism, we administered APAP at subtoxic (150 mg/kg ip) and toxic (500 mg/kg ip) doses to overnight fasted mice. Animals were sacrificed at different time points from 15 min to 4 h postinjection. We assessed liver toxicity by plasma ALT activity and by electr...

Calcineurin inhibitors (cyclosporine and tacrolimus; CNIs) continue to be used as constituents of post-transplant immunosuppression in most centers. However, renal toxicity associated with the use of these drugs remains a problem adversely affecting the long-term graft survival. Fifteen adequate protocol renal allograft biopsies, with histological features of CNI toxicity among 140 protocol bio...

Background: Research on animal toxins have shown toxicity potential cancerous cell and tissues in the cultures. Conotoxins obtained from marine cone snails show highest potential, so that several human deaths been attributed to this species of snail. These proven be valuable agents inhibit enzymes, channels proteins, nervous systems humans. Methods: We studied effects Conus textile crude venom ...

The raw data showed in this article comes from the published research article entitled "Protective effects of Chlorogenic acid in 3-Nitropropionic acid induced toxicity and genotoxicity" Food Chem Toxicol. 2017 May 3. pii: S0278-6915(17)30226-0. DOI:10.1016/j.fct.2017.04.048. [1]. Data illustrates antitoxic and antigenotoxic effects of Chlorogenic acid (CGA) on toxicity and genotoxicity produce...

in this study the uptake and metabolism of adenosine by mitochondria has been investigated. incubation of cem cells mitochondria preparation with [3h] -adenosine showed substantial uptake and metabolism of adenosine. adenosine was both anabolized to amp, adp and atp, and also catabolized to inosine. the highest concentration of metabolites in extracted mitochondria was due to amp. the mitochond...

Amyloid beta (Abeta) plays a critical role in the pathophysiology of Alzheimer's disease. Increasing evidence indicates mitochondria as an important target of Abeta toxicity; however, the effects of Abeta toxicity on mitochondria have not yet been fully elucidated. Recent biochemical studies in vivo and in vitro implicate mitochondrial permeability transition pore (mPTP) formation involvement i...

Alzheimer’s disease (AD) is the most common chronic neurodegenerative worldwide. It causes cognitive dysfunction, such as aphasia and agnosia, mental symptoms, behavioral abnormalities; all of which place a significant psychological economic burden on patients’ families. No specific drugs are currently available for treatment AD, current AD only delay onset progression. The pathophysiological b...

Corwin, L. M. (Walter Reed Army Medical Center, Washington, D.C.), and W. E. Farrar, Jr. Nature of the endotoxin-inactivating principle in guinea-pig liver. J. Bacteriol. 87:832-837. 1964.-Guinea-pig liver preparations inactivate Serratia marcescens endotoxin as assayed in chick embryo. The activity is optimal at pH 6.5 to 7.0 and 8.5 to 9.0. Mitochondria and the supernatant fraction containing...