Cytoplasmic effects on plant performance are well-documented and result from the intimate interaction between organellar and nuclear gene products. In plants, deletions, mutations, or chimerism of mitochondrial genes are often associated with deleterious phenotypes, as well as economically important traits such as cytoplasmic male sterility used to produce hybrid seed. Presently, genetic analys...

D. Mérino, M. Giam, and P.D. Hughes contributed equally to this paper. Correspondence to Philippe Bouillet: [email protected] O.M. Siggs’ present address is Dept. of Genetics, The Scripps Research Institute, La Jolla, CA 92037. Abbreviations used in this paper: MOMP, mitochondrial outer membrane permeabilization; PKD, polycystic kidney disease; tBid, truncated Bid; WBC, white blood cell; WT,...

Several inherited metabolic disorders have been associated with stroke particularly in newborns, children, and young adults. In part 1, we discussed the genetics, stroke pathophysiology, clinical presentation, diagnosis, and treatment of Fabry disease and mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes. In part 2, we overview homocystinuria, organic acidurias, a...

background: polycystic ovary syndrome (pcos) is a complex disease having both genetic and environmental components and candidate genes on obesity and insulin metabolism have been hypothesized to be involved in its etiology. objective: we examined the possible association of adiponectin and insulin receptor gene polymorphisms with pcos. materials and methods: a total of 186 women with pcos using...

Evolution algebra theory is used to study non-Mendelian inheritance, particularly organelle heredity and population genetics of Phytophthora infectans. We not only can explain a puzzling feature of establishment of homoplasmy from heteroplasmic cell population and the coexistence of mitochondrial triplasmy, but also can predict all mechanisms to form the homoplasmy of cell populations, which ar...

Evolution algebra theory is used to study non-Mendelian inheritance, particularly organelle heredity and population genetics of Phytophthora infectans. We can not only explain a puzzling feature of establishment of homoplasmy from heteroplasmic cell population and the coexistence of mitochondrial triplasmy, but also predict all mechanisms to form the homoplasmy of cell populations, which are hy...