Abstract: The present investigation deals with the multi component machine repair problem by including the concepts of reneging and interdependent controlled rates. We consider a machining system consisting of M operating units, S1 and S2 warm spares of two kinds and a repair facility having R permanent repairmen and r additional removable repairmen. When all the spares are used and the operati...

UNLABELLED We recently developed a small molecule inhibitor SMI#9 for Rad6, a protein overexpressed in aggressive breast cancers and involved in DNA damage tolerance. SMI#9 induces cytotoxicity in cancerous cells but spares normal breast cells; however, its therapeutic efficacy is limited by poor solubility. Here we chemically modified SMI#9 to enable its conjugation and hydrolysis from gold na...

Ovarian cancer is the fifth leading cause of deaths due to cancer among women in the United States. In 2017, 22,440 women are expected to be diagnosed with ovarian cancer and 14,080 women will die with it. Currently used chemotherapies (Cisplatin or platinum/taxane combination) targets cancer cells, but spares cancer stem cells (CSCs), which are responsible for tumor relapse leading to recurren...

Although the differential flow of metabolites through alternate pathways of intermediary metabolism is thought to be an important functional cause of life-history trade-offs, this phenomenon remains understudied. Using a radiolabeled amino acid, we quantified genetic differences in in vivo amino acid metabolism between morphs of the wing-polymorphic cricket Gryllus firmus that trade off early-a...

Byzantine fault tolerant state machine replication (BFT-SMR) is a foundation for implementations of highly reliable services. Existing algorithms for BFT-SMR require at least 3f +1 active replicas to tolerate f faulty replicas. We show that BFT-SMR can be achieved with fewer than 3f +1 active replicas, as long as standby spare replicas are available, such that the number of active replicas plus...

With a need for faster access to new technologies located beyond their boundaries and capabilities, firms may seek strategic advantage from supply chain partners. Strategic alliances are frequently encountered in high technology applications where individual firms lack expertise or the means to embark on uncertain business ventures. Since some products no longer offer distinctive advantage, org...

Digital computers embedded in critical applications such as flight controls should be equipped with appropriate fault-tolerance schemes to ensure their reliable and safe operation in the presence of component failures. System reconfiguration, which enhances reliability by dynamically using spatial redundancy, is generally the most time-consuming faul t/errorhandling stage. The reconfigurutzon l...

We consider an M/G/∞ exchangeable-item repair system with spares and ample servers to which arriving customers bring groups of random size B identical items for repair. An exact formula for the waiting time distribution and a computationally efficient approximation are presented for this system. From this, we not only have the standard fillrate, but a practical extension of this concept to a 'f...

Previous studies showed that administration of ascorbate to glutathione (GSH)-deficient newborn rats and guinea pigs prevented toxicity and mortality and led to increased tissue and mitochondrial GSH levels; ascorbate thus spares GSH. In the present work, we tried to answer the converse question: Does administration of GSH spare ascorbate? Because administered GSH is not well transported into m...

Almost every modern chemical process is equipped with a heat-exchanger network (HEN) for optimal energy recovery. However, as time goes on after startup, fouling on the heat-transfer surface in an industrial environment is unavoidable. If the heat exchangers in an operating plant are not cleaned regularly, the targeted thermal efficiency of HEN can only be sustained for a short period of time. ...