OBJECTIVE Matrix metalloproteinases (MMPs) and the angiogenic proteins basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) have been implicated in mechanisms of human cancer and metastasis. Assays were conducted on the urine of patients with vascular anomalies (tumors and malformations), relatively common and occasionally life-threatening disorders for which few ...

Matrix metalloproteinases (MMP) are crucial for homeostasis (tissue remodelling and repair, bone growth, wound healing, etc.) and pathology (metastasis, angiogenesis, aneurysm rupture, etc.). Upregulated MMPs from macrophages are thus a two-edged sword, playing both defensive and aggressive roles. The related family of ADAMs (a disintegrin and a metalloproteinase) is sometimes overlooked becaus...

Background Allergic rhinitis (AR) and asthma share many characteristics, but structural changes are observed far less often in AR as compared to asthma and also that in nasal polyps. Matrix metalloproteinases (MMPs) can decompose the extracellular matrix and regulate cell infiltration. In order to understand the role of MMPs in AR, we analyzed the expression of MMPs and their inhibitors, tissue...

Photoaging mainly occurs due to ultraviolet (UV) radiation, and is accompanied by increased secretion of matrix metalloproteinases (MMPs) degradation collagen. UV radiation induces cell senescence in the skin; however, role senescent cells photoaging remains unclear. Therefore, elucidate photoaging, we evaluated effect senolytics a mouse model investigated underlying mechanism their antiaging e...

The imbalance in the expression of matrix metalloproteinases (MMPs) and lysyl oxidases (LOXs) synovial fibroblasts (SFs) caused by mechanical injury inflammatory response prevents injured anterior cruciate ligaments (ACLs) from self-healing. However, research on effect growth factors SFs regulating microenvironment is limited. In this study, exogenous transform factor-β1 (TGF-β1) were employed ...

Abstract This study aims to investigate the beneficial effects of exosomes derived from bone marrow mesenchymal stem cells (BMSCs) on trabecular meshwork under oxidative stress and predict candidate genes associated with this process. Trabecular were pretreated BMSC-derived for 24 h, exposed 0.1 mM H 2 O 6 h. Survival rate was measured CCK-8 assay. Production intracellular reactive oxygen speci...

An estimated 15 million people in the UK menstruate over span of approximately 37.5 years, using every year around 3.3 billion units single-use menstrual management products (MMPs) (i.e. pads and tampons). A more circular design sustainable these could greatly reduce their waste environmental impacts. This research is an exploratory study into current products, systems UK. The found that 28,114...

We examined the connection between matrix metalloproteinase (MMP) expression/activity and pterygium fibroblast migration, and how these were affected by bevacizumab and/or cyclosporine A (CsA). Fibroblasts were obtained from 20 pterygia and 6 normal conjunctival specimens. Expression levels of MMP-3 and MMP-13 were examined after bevacizumab administration. Immunofluorescence staining was used ...

BACKGROUND Extended culture of monocytes and fibroblasts in three-dimensional collagen gels leads to degradation of the gels (see linked study in this issue, "Fibroblasts and monocytes contract and degrade three-dimensional collagen gels in extended co-culture"). The current study, therefore, was designed to evaluate production of matrix-degrading metalloproteinases by these cells in co-culture...

Atherosclerosis is an inflammatory process that involves activation of matrix metalloproteinases (MMPs); MMPs degrade collagen and allow for smooth-muscle cell migration within a vessel. Moreover, this begets an accumulation of other cellular material, resulting in occlusion of the vessel and ischemic events to tissues in need of nutrients. Homocysteine has been shown to activate MMPs via an in...