Abstract The prostate gland is highly susceptible to oncogenic transformation, many times more than other sex tissues, such as seminal vesicles. In fact, cancer (PCa) will be diagnosed in one seven lifetime patients, making PCa the subject of intense research aimed at clarifying its biology and providing adequate treatment. fourth most common world terms overall population second for male popul...

The problem of obesity in modern life is becoming more actual and a serious social risk for human life. This common despite professional affiliation, location, age gender. Obesity associated with an increase growth adipose tissue. Today isn't studied only as excessive accumulation fat the body, but chronic multivariate disease number metabolic, oncological, cardiological other complications. Al...

We examined the connection between matrix metalloproteinase (MMP) expression/activity and pterygium fibroblast migration, and how these were affected by bevacizumab and/or cyclosporine A (CsA). Fibroblasts were obtained from 20 pterygia and 6 normal conjunctival specimens. Expression levels of MMP-3 and MMP-13 were examined after bevacizumab administration. Immunofluorescence staining was used ...

Free radicals play an important role in cerebral ischemia-reperfusion injury. Accumulations of toxic free radicals such as reactive oxygen species (ROS) and reactive nitrogen species (RNS) not only increase the susceptibility of brain tissue to ischemic damage but also trigger numerous molecular cascades, leading to increased blood-brain barrier (BBB) permeability, brain edema, hemorrhage and i...

Blood-brain barrier (BBB) formed by brain microvascular endothelial cells (BMVEC) regulates the passage of molecules and leukocytes in and out of the brain. Activation of matrix metalloproteinases (MMPs) and alteration of basement membrane (BM) associated with BBB injury was documented in stroke patients. While chronic alcoholism is a risk factor for developing stroke, underlying mechanisms are...

Matrix metalloproteinases (MMPs) are mediators of lung injury, and their activity has been associated with the development of pulmonary fibrosis. To understand how MMPs regulate the development of pulmonary fibrosis, we examined MMP expression in two strains of mice with differing sensitivities to the fibrosis-inducing drug bleomycin. After a single intratracheal injection of the drug, bleomyci...

Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade the components of the extracellular matrix (ECM). The balance between MMPs and their inhibitors [tissue inhibitors of metalloproteinases (TIMPs)] in the pericellular environment determines the most significant proteolytic events in tissue remodeling. In vitro evidence is accumulating that these molecules may be crucial in the...

BACKGROUND/AIM Matrix metalloproteinases (MMPs) are proteolytic enzymes capable of degrading almost all extracellular matrix and basement membrane components in many destructive pathological processes, such as chronic inflammation and bone-destructive lesions. The aim of this study was to determinate the correlation between concentration of collagenases (MMP-1, -8, -13) in chronic periapical le...

Matrix metalloproteases (MMPs) are important enzymes required in extracellular matrix (ECM) degradation for creating the cellular environments to maintain numerous physiological processes ranging from development to wound repair. However, MMP activity is strictly controlled and imbalance in the levels of MMP family members and its inhibitors has been implicated as an etiological factor in sever...

Matrix metalloproteinases (MMPs) represent a diverse family of nzymes that historically were identified by their ability to proteoytically cleave proteins within the extracellular matrix. With furher investigation, additional substrates for these enzymes have een identified and the number of proteins within the family has xpanded to over 20 different species. Along with the identification of he...