objective(s): this study describes the preparation, biodistribution of 153sm-dtpa-spion after intravenous injection in rats. materials and methods: the chelator dtpa dianhydride was conjugated to spion using a small modification of the well-known cyclic anhydride method. conjugation was done at a 1: 4 (spion: ccdtpa) molar ratio. conjugation reaction was purified with magnetic assorting column ...
