A high-quality hemoglobinopathy diagnosis is based on the results of a number of tests including assays for molecular identification of causative mutations. We describe the current diagnostic strategy for the identification of β-thalassemias and hemoglobin (Hb) variants at the International Reference Laboratory for Haemoglobinopathies, Research Centre for Genetic Engineering and Biotechnology (...

Biotechnology has been globally accepted as one of the important tools for direct application in agriculture. Agricultural biotechnology includes plant tissue culture (PTC), applied microbiology, and molecular biology contributing to production crops with improved food, feed, fiber fuel. The technique PTC is well translated from ‘concept’ ‘commercialization’. It flourishing multidirectional gro...

Research on rumen microorganisms has contributed greatly to our understanding of anaerobic microbial ecosystems, and has also influenced feeding practices and nutritional modelling with ruminants. However, it can be argued that rumen microbiology has not yet fulfilled its true potential. Growth-promoting ionophores, antibiotics and microbial feed additives were introduced before their microbiol...

Modeling of molecular interactions is increasingly used in life science research and biotechnology development. Examples are computer aided drug design, prediction of protein interactions with other molecules, and simulation of networks of biomolecules in a particular process in human body. This article reviews recent progress in the related fields and provides a brief overview on the methods u...

abstract        typing of bacteria is an important part of epidemiological studies on nosocomial infections. bacterial identification methods have dramatically improved in recent years, which is mainly due to advancements in the field of molecular biotechnology. in many cases, molecular techniques have replaced phenotypic typing methods. currently, a wide range of bacterial typing techniques is...

The specific structural features of stem-loop (hairpin) DNA constructs provide increased specificity of target recognition. Recently, several robust assays have been developed that exploit the potential of structurally constrained oligonucleotides to hybridize with their cognate targets. Here, I review new diagnostic approaches based on the formation of stem-loop DNA oligonucleotides: molecular...

1. Unit of Molecular Endocrinology, Sousse Faculty of Medicine, University of Sousse, Sousse, Tunisia 2. Laboratory of Human Cytogenetics, Molecular Genetics and Reproductive Biology. Farhat Hached University Hospital, Sousse, Tunisia 3. Higher Institute of Biotechnology of Monastir, University of Monastir, Tunisia 4. Dept. of Endocrinology and Diabetology, Farhat Hached University Hospital, So...

Jifen Li*, Steven Goossens, Jolanda van Hengel, Erhe Gao, Lan Cheng, Koen Tyberghein, Xiying Shang, Riet De Rycke, Frans van Roy* and Glenn L. Radice Center for Translational Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, PA, USA Department for Molecular Biomedical Research, Flanders Institute for Biotechnology (VIB), B-9052 Ghent, Belgium Department of Biomedical ...

ARC Centre in Bioinformatics and Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia Department of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia Institute of Biological Sciences, University of Malaya, 50603 Kuala Lumpur, Malaysia University of Malaya Mar...

Willem H. J. Westerhuis,† C. Neil Hunter,† Rienk van Grondelle,‡ and Robert A. Niederman*,§ Department of Molecular Biology and Biotechnology, UniVersity of Sheffield, Sheffield S10 2TN, U.K., Department of Biophysics, Faculty of Physics and Astronomy, Free UniVersity, De Boelelaan 1081, 1081 HV Amsterdam, The Netherlands, and Department of Molecular Biology and Biochemistry, Rutgers UniVersity...