Genetic factors for many decades have been known to play a critical role in the etiology of diabetes, but it has been only recently that the specific genes have been identified. The identification of the underlying molecular genetics opens the possibility for understanding the genetic architecture of clinically defined categories of diabetes, new biological insights, new clinical insights, and ...

Genetics have undoubtedly become an integral part of biomedical science and clinical practice, with important implications in deciphering disease pathogenesis and progression, identifying diagnostic and prognostic markers, as well as designing better targeted treatments. The exponential growth of our understanding of different genetic concepts is paralleled by a growing list of genetic terminol...

Brain tumors are the leading cause of cancer death in children, with ependymoma being the third most common and posing a significant clinical burden. Its mechanism of pathogenesis, reliable prognostic indicators, and effective treatments other than surgical resection have all remained elusive. Until recently, ependymoma research was hindered by the small number of tumors available for study, lo...

.................................................................................................................8 INTRODUCTION......................................................................................................10 REVIEW OF THE LITERATURE .........................................................................12 1. Mapping of complex diseases ....................................

Molecular population genetics aims to explain genetic variation and molecular evolution from population genetics principles. The field was born 50 years ago with the first measures of genetic variation in allozyme loci, continued with the nucleotide sequencing era, and is currently in the era of population genomics. During this period, molecular population genetics has been revolutionized by pr...

Medical Microbiology & Infectious Diseases: Computerized Teaching Materials and References: Examples of lectures, teaching materials, syllabi, objectives and a disease index can be found at the Kirksville College of Osteopathic Medicine website. Included are Clinical Cases; an Infectious Disease Laboratory Manual; Common Causes of Various Diseases; Notifiable Diseases; Skin Rashes-Diseases; etc...

Methods: A cohort of 48 patients with MFC was compared with previously characterized cohorts of patients with advanced AMD (368 samples) and matched unaffected controls (368 samples). Allele and genotype frequencies of single nucleotide polymorphisms for the following AMD-associated alleles were evaluated: risk alleles in complement factor H (CFH) gene (Y402H and IVS14) and LOC387715/HTRA1 gene...

T he question of how traits and behaviors pass from one generation to the next has been the subject of intense interest throughout the history of science. Simple parent–child correlations are open to multiple interpretations, as parents transmit both environment and genome to their children. Until recently, genotyping—or the direct measurement of variation in an individual’s DNA sequence throug...