When a cell’s DNA is damaged, the injured cells react by changing from normal to malignant cells, rather than dying or repairing the damage. Metastatic cancer is the deadliest kind of cancer since it refers to cancer that has spread to other parts of the patient’s body. The need for cancer detection techniques that are rapid, non-invasive, and accurate is growing. Cancer diagnosis, monitoring, ...

After its emergence in 2003, a livestock-associated (LA-)MRSA clade (CC398) has caused an impressive increase in the number of isolates submitted for the Dutch national MRSA surveillance and now comprises 40% of all isolates. The currently used molecular typing techniques have limited discriminatory power for this MRSA clade, which hampers studies on the origin and transmission routes. Recently...

we prove a strong convergence result for a sequence generated by halpern's type iteration for approximating a common fixed point of a countable family of quasi-lipschitzian mappings in a real hilbert space. consequently, we apply our results to the problem of finding a common fixed point of asymptotically nonexpansive mappings, an equilibrium problem, and a variational inequality problem for co...

Genetic mapping (also known as linkage mapping or meiotic mapping) refers to the determination of the relative position and distances between markers along chromosomes. Genetic map distances between two markers are defined as the mean number of recombination events, involving a given chromatid, in that region per meiosis. Genetic map construction requires that the researcher develop appropriate...

The force fields used in molecular computational biology are not mathematically defined in such a way that their mathematical representation would facilitate the straightforward application of volume visualization techniques. To visualize energy, it is necessary to define a spatial mapping for these fields. Equipped with such a mapping, we can generate volume renderings of the internal energy s...

We have prepared a molecular map of the Chlamydomonas reinhardtii genome anchored to the genetic map. The map consists of 264 markers, including sequence-tagged sites (STS), scored by use of PCR and agarose gel electrophoresis, and restriction fragment length polymorphism markers, scored by use of Southern blot hybridization. All molecular markers tested map to one of the 17 known linkage group...

Ephrin/Eph ligands and receptors are best known for their prominent role in topographic mapping of neural connectivity. Despite the large amount of work centered on ephrin/Eph-dependent signaling pathways in various cellular contexts, the molecular mechanisms of action of Eph receptors in neural mapping, requiring dynamic interactions between complementary gradients of ephrins and Eph receptors...

INTRODUCTION Class I HLA's polymorphism has hampered CTL epitope mapping with laborious experiments. Objectives are 1) to evaluate the novel in silico model in predicting previously reported epitopes in comparison with existing program, and 2) to apply the model to predict optimal epitopes with HLA using experimental results. MATERIALS AND METHODS We have developed a novel in silico epitope p...