The selective action that steroid hormones and the hormones for the other nuclear receptors have in different tissues and on different responses is well known. In fact, this recognized selectivity forms the basis for major efforts, currently underway in the pharmaceutical industry and at universities, toward the development of new, synthetic hormones whose profile of desired activities is optim...

Ketamine was introduced into clinical practice in the 1960s and continues to be both clinically useful and scientifically fascinating. With considerably diverse molecular targets and neurophysiological properties, ketamine's effects on the central nervous system remain incompletely understood. Investigators have leveraged the unique characteristics of ketamine to explore the invariant, fundamen...