The concepts of intrinsic mode functions and mono-components are investigated in relation to the empirical mode decomposition. Mono-components are defined to be the functions for which non-negative analytic instantaneous frequency is well defined. We show that a great variety of functions are mono-components based on which adaptive decomposition of signals are theoretically possible. We justify...

In order to better understand the chiral recognition mechanisms of positively charged cyclodextrin (CD) derivatives, synthesis, pKa determination by 1H nuclear magnetic resonance (NMR)-pH titration and a comparative capillary electrophoretic (CE) study were performed with two series mono-substituted cationic single isomer CDs. The first selectors mono-(6-N-pyrrolidine-6-deoxy)-β-CD (PYR-β-CD), ...

The effects of mono- and dibutyl phthalate and mono- and di(2-ethylhexyl) phthalate on energy-dependent K+ uptake, respiration rates, and succinate cytochrome c reductase activities of isolated rat liver mitochondria were evaluated. The energy-coupling processes, active K+ transport and oxidative phosphorylation, were affected most by di-n-butyl phthalate and mono(2-ethylhexyl) phthalate. Mono-...

Methoxychlor, a currently used pesticide, is a proestrogen exhibiting estrogenic activity in mammals in vivo. Methoxychlor undergoes oxidative metabolism by cytochromes P450, yielding 1,1,1-trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane (mono-OH-M) and 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane (bis-OH-M) as main metabolites. Since humans may be exposed to these estrogenic metaboli...

Block copolymer micellar templates were used for the controlled synthesis of large arrays of mono-metallic (Fe, Co, Ni, Mo) and bi-metallic (Fe–Mo) nanoparticles with average diameters ranging from 1 to 4 nm and the distance between the nanoparticles ranging from 40 to 45 nm. XPS data reveal the presence of mono-metallic nanoparticles in their oxidized states. These uniform arrays of nanopartic...

We apply a geospeedometer previously developed in this lab to investigate cooling rate profiles of rhyolitic samples initially held at 720^750‡C and quenched in water, liquid nitrogen, and air. For quench of mm-size samples in liquid nitrogen and in air, the cooling rate is uniform and is controlled by heat transfer in the quench medium instead of heat conduction in the sample. The heat transfe...

Recombinant human granulocyte colony stimulating factor (rhG-CSF) and its PEGylated product "mono-PEG20-GCSF" have already been widely used for treatment of all kinds of neutropenia. However, the high required dosage of mono-PEG20-GCSF made it relatively expensive in clinical use. We postulated that an N-terminal site-specific PEGylated rhG-CSF with higher PEG Mw (PEG30 kDa) might be able to ac...

In this paper, electronic, structural, and spectroscopic properties of mono-, di-, tri-, andtetrafluorothiophenes and their radical cations are studied using the density functional theory andB3LYP method with 6-311++G** basis set. Also the effects of the number and position of thesubstituent on the electrochemical properties of the thiophene ring have been studied usingoptimized structures obta...

BACKGROUND Isoniazid and rifampicin are the two most efficacious first-line agents for tuberculosis (TB) treatment. We assessed the prevalence of isoniazid and rifampicin mono-resistance, associated risk factors, and the association of mono-resistance on treatment outcomes. METHODS A prospective, observational cohort study enrolled adults with a first episode of smear-positive pulmonary TB fr...