Aromatic essential oils play a significant role in pharmaceuticals, food additives, cosmetics, and perfumery. Essential mostly comprise aliphatic hydrocarbons, monoterpenoids, sesquiterpenoids diterpenes. Plant extracts complex mixture of terpenes, terpenoids, phenol-derived aromatic components. Terpenes are class hydrocarbons with numerous health benefits. These biological functions oil compon...

Usnic acid (UA) is a secondary metabolite of lichens that exhibits wide range biological activities. Previously, we found UA derivatives are effective inhibitors tyrosyl-DNA phosphodiesterase 1 (TDP1). It can remove covalent complex DNA-topoisomerase (TOP1) stabilized by the TOP1 inhibitor topotecan, neutralizing effect drugs. TDP1 removes damage at 3′ end DNA caused other anticancer agents. Th...

The chemical profiles of Rosmarinus officinalis L. essential oils, collected from five distinct geographical regions in Palestine, were determined using GC-MS. major phytochemical classes R. EOs monoterpene hydrocarbon (24.81–78.75%) and oxygenated monoterpenoids (19.01–73.78%), with 1,8-cineole (4.81–37.83%), α-pinene (13.07–51.36%), camphor (11.95–24.30%) being the most abundant components st...

Esters based on mono- and bicyclic terpenoids with glycine have been synthesized via Steglich esterification and characterized by ¹H-NMR, IR, and mass spectral studies. Their analgesic and anti-inflammatory activities were investigated after transdermal delivery on models of formalin, capsaicin, and AITC-induced pain, respectively. Glycine esters of menthol and borneol exhibited higher antinoci...