نتایج جستجو برای: montanide
تعداد نتایج: 327 فیلتر نتایج به سال:
PURPOSE To determine the toxicity, safety, and immunogenicity of a human papillomavirus 16 (HPV16) E6 and E7 long peptide vaccine administered to end-stage cervical cancer patients. EXPERIMENTAL DESIGN Three groups of end-stage cervical cancer patients (in total n = 35) were s.c. vaccinated with HPV16 E6 combined with or separated from HPV16 E7 overlapping long peptides in Montanide ISA-51 ad...
Long-term immunity to coronaviruses likely stems from T cell activity. We present here a novel approach for the selection of immunoprevalent SARS-CoV-2-derived epitopes using an in silico cohort HLA-genotyped individuals with different ethnicities. Nine 30-mer peptides derived four major structural proteins SARS-CoV-2 were selected and included peptide vaccine candidate recapitulate broad virus...
PURPOSE The study aims to evaluate the effect of a human papillomavirus type 16 (HPV16) E6 and E7 synthetic long peptides vaccine on the antigen-specific T-cell response in cervical cancer patients. EXPERIMENTAL DESIGN Patients with resected HPV16-positive cervical cancer were vaccinated with an overlapping set of long peptides comprising the sequences of the HPV16 E6 and E7 oncoproteins emul...
Glycosylation is of importance for the structure and function of proteins. In the case of vitellin (Vt), a ubiquitous protein accumulated into granules as the main yolk protein constituent of oocytes during oogenesis, glycosylation could be of importantance for the folding, processing and transport of the protein to the yolk and also provides a source of carbohydrate during embryogenesis. Vt fr...
Isolation of viral pathogens from clinical and/or animal samples has traditionally relied on either cell cultures or laboratory animal model systems. However, virus viability is notoriously susceptible to adverse conditions that may include inappropriate procedures for sample collection, storage temperature, support media and transportation. Using our recently described ISA method, we have deve...
In this study, we report on the safety and skin delayed-type hypersensitivity (DTH), responses of the Leishmania donovani whole cell sonicate antigen delivered in conjunction with alum-BCG (AlBCG), Montanide ISA 720 (MISA) or Monophosphoryl lipid A (MPLA) in groups of vervet monkeys. Following three intradermal injections of the inoculums on days 0, 28 and 42, safety and DTH responses were asse...
The use of recombinant tumor antigen proteins is a realistic approach for the development of generic cancer vaccines, but the potential of this type of vaccines to induce specific CD8(+) T cell responses, through in vivo cross-priming, has remained unclear. In this article, we report that repeated vaccination of cancer patients with recombinant NY-ESO-1 protein, Montanide ISA-51, and CpG ODN 79...
Purpose: Long peptides are efficiently presented to both CD4þ and CD8þ T cells after intracellular processing by antigen-presenting cells. To investigate the safety and in vivo immunogenicity of synthetic overlapping longpeptides (OLP) fromahuman tumor self-antigen,we conducted aphase I clinical trialwith OLP from cancer-testis antigen NY-ESO-1 in various adjuvant combinations. Experimental Des...
In spite of extensive efforts, even the most experienced laboratories dealing with isotopic measurements of atmospheric CO2 still suffer from poor inter-laboratory consistency. One of the complicating factors of these isotope measurements is the presence of N2O, giving rise to mass overlap in the isotope ratio mass spectrometer (IRMS). The aim of the experiment reported here has been twofold: f...
Context. BP Cru is a well known high-mass X-ray binary composed of a late B hypergiant (Wray 977) and a neutron star, also observed as the X-ray pulsar GX301-2. No information about emission from BP Cru in other bands than X-rays and optical has been reported to date in the literature, though massive X-ray binaries containing black holes can have radio emission from a jet. Aims. In order to ass...
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