BACKGROUND "Vacuolated" eosinophils (ie, eosinophils with empty, nonstaining granules) have been described previously in normal Greyhounds. However, to our knowledge, detailed studies of granules in vacuolated and normal eosinophils in this breed have not been performed. OBJECTIVE The objective of this prospective study was to characterize some of the morphologic, ultrastructural, and cytoche...

OBJECTIVE To develop an interpretation procedure which estimates simulation parameters (tumour cell motility, tumour cell adhesion, autocrine and paracrine growth control, stroma destruction) of simulated patterns solely based on morphometric features of the morphologic pattern. METHODS A cellular automaton computer simulation program was developed which produces morphologic patterns by growt...

This paper is a retrospective morphologic study of 7 young Boxer dogs, showing end-stage kidney lesions compatible with chronic pyelonephritis with severe segmental cortical atrophy and fibrosis, associated with chronic tubulointerstitial inflammation of varying degree. Azotemia was observed in 6 of the 7 cases. The gross kidney lesions were as follows: bilateral small kidneys with numerous seg...

Preputial gland neoplasms in the Fischer 344 rat are relatively uncommon tumors with a prevalence of approximately 3% in the National Toxicology Program data base. They occur late in life, are well differentiated, and rarely metastasize. Based on studies through 4 serial passages, 10 well-differentiated preputial gland neoplasms transplanted into the mammary fat pads of syngeneic recipients gre...