Abstract Objective To investigate the cutaneous silent period (CSP) by measuring its onset latency, duration and amount signal suppression in patients with motor neuron disease (MND) grouped according to intensity of upper involvement (UMN), test effect contralateral hand contraction. Methods Painful stimulation was applied at V finger, contraction recorded from abductor digiti minimi (ADM) mus...

Because microglial cells, the resident macrophages of the CNS, react to any lesion of the nervous system, they have for long been regarded as potential players in the pathogenesis of several neurodegenerative disorders including Amyotrophic Lateral Sclerosis, the most common motor neuron disease in the adult. In recent years, this microglial reaction to motor neuron injury, in particular, and t...