Oral dosage forms are the most popular form of medication, although there some problems compared to others methods such as risk drug absorption, which can be overcome by administering in a liquid form, therefore, perhaps allow for use low doses. However, instability many drugs reduces their use. Formulation Effervescent tablets/granules used an alternative developing that accelerate dispersion ...

The acute wound healing process requires a quick and short-stage vascular endothelial growth factor (VEGF) supply, especially, in the early-stage of injury. To date, research has rarely met demand for controlled VEGF release. Herein, novel wheel spinning technique was introduced to fabricate alginate (Alg)/silk fibroin (SF) composite fiber loading achieving controllable In turn, it demonstrated...

The movement of the penetrant and polymer fronts and the drug dissolution in highly loaded swellable matrix tablets were studied with the aim of establishing relationships between front position and drug release kinetics. Three boundaries were identified corresponding to the swelling, diffusion and erosion fronts. The kinetics of drug release depended on the relative movement of the erosion and...

In this work, molecular dynamics simulation is conducted to explore the shock wave phenomena in a nanodomain in near-field laser–material interaction. A large system consisting of over 800,000 atoms is studied. The work focuses on the kinetic and physical properties of the disturbed gas compression driven by the high speed movement of the molten particulates ejected from the solid target in a n...

Good outcomes have been reported after both open and percutaneous surgery to release trigger thumb. This study evaluated short-term and long-term outcomes after treatment of trigger thumb with open or percutaneous release. A total of 126 trigger thumbs in 107 patients were reviewed from 2009 to 2012. Short-term (3 months) and long-term results (2 years) and complications of open release (58 dig...

the transport of dissolved contaminants in groundwater is usually described by the advectiondispersion equation with reaction. several numerical methods for solving the one-dimensional are availableincluding finite difference methods, finite volume methods, and finite element methods. stringent conditions,such as small peclet (pe) and courant (cr) numbers, must be satisfied to ensure the accura...

blood pressure rises rapidly upon awakening and maybe responsible, in part, for the increased incidence of myocardial infarction and stroke during the morning hours. the aim of the present study was, therefore, to develop a novel chronotherapeutic formulation of metoprolol tartrate (mt) for night time dosing providing maximum effect in the morning hours. core tablets contained mt, sodium chlori...

Extracellular release of platelet activating factor (PAF) following synthesis in inflammatory cells is variable and modulated by a number of as yet undefined cellular mechanisms. Using human neutrophils loaded with the tritiated, nonmetabolizable PAF analog, 1-O-alkyl-2-N-methylcarbamyl-sn-glycero-3-phosphocholine (C-PAF), extracellular release was studied by techniques involving an albumin ext...

Four manifestations of excitation-contraction (E-C) coupling were derived from measurements in cut skeletal muscle fibers of the frog, voltage clamped in a Vaseline-gap chamber: intramembranous charge movement currents, myoplasmic [Ca2+] transients, flux of calcium release from the sarcoplasmic reticulum (SR), and the intrinsic optical transparency change that accompanies calcium release. In at...

A pattern-based approach to the presentation, codi cation and reuse of property speci cations for nite-state veri cation was proposed by Dwyer and his colleagues in [4,3]. The patterns enable nonexperts to read and write formal speci cations for realistic systems and facilitate easy conversion of speci cations between formalisms, such as LTL, CTL, QRE. In this paper we extend the pattern system...